| Effects of surplus dietary L-tryptophan on stress, immunology, behavior, and nitrogen retention in endotoxemic pigs. | |
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MedLine Citation:
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PMID: 21856896 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The possible beneficial effects of surplus dietary Trp (+ 5 g Trp/kg diet) were investigated on factors related to stress, immunology, behavior, and N retention in post-weaning piglets (approximately 15 kg BW) challenged for 10 d with intravenous bacterial lipopolysaccharide (LPS; from Escherichia coli). Two diets fed restrictively (732 kJ NE/kg BW(0.75)/d) were compared: 1) basal diet (B; apparent ileal digestible Trp = 1.9 g/kg; a recommended level of Trp to warrant near-optimal growth in non-endotoxemic piglets) and 2) Trp enriched B (+ 5 g free L-Trp/kg) with 8 individually housed piglets per diet. Pooled salivary cortisol, but not plasma cortisol sampled at sacrifice, showed a tendency (P = 0.07) towards reduced concentrations in the Trp group (1.1 vs. 1.4 ng/mL; pooled SE = 0.1 ng/mL). Plasma C-reactive protein was reduced (P = 0.04) in the Trp group (0.9 vs. 5.0 mg/L; pooled SE = 1.3 mg/L), but haptoglobin, IL-6, tumor necrosis factor alpha, and LPS-induced fever were similar between the 2 dietary treatments. Physical activity related to approaching a human showed a tendency (P = 0.08) towards increased latency time in the Trp group (101 vs. 60 s; pooled SE = 16 s) but the times spent on standing, sitting, and lying were similar between dietary treatments. The ADFI, ADG (346 vs. 302 g/d; pooled SE = 14 g/d; P = 0.11), body N retention (11.6 vs. 11.0 g/d; pooled SE = 0.2 g/d; P = 0.18), and G:F (0.55 vs. 0.49; pooled SE = 0.03; P = 0.17) were not different between the Trp and B fed groups. In conclusion, surplus dietary Trp has limited impact on stress, immunology, behavior, and N retention in a pig model of systemic endotoxemia. |
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Authors:
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S J Koopmans; F J van der Staay; N Le Floc'h; R Dekker; J Th M van Diepen; A J M Jansman |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-19 |
Journal Detail:
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Title: Journal of animal science Volume: - ISSN: 1525-3163 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8003002 Medline TA: J Anim Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Animal Sciences, Adaptation Physiology Group of Wageningen University, Wageningen, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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