Document Detail

Effects of surgical skin incision on respiration in patients anaesthetized with enflurane.
MedLine Citation:
PMID:  8679348     Owner:  NLM     Status:  MEDLINE    
We measured ventilation in 12 subjects anaesthetized with enflurane (end-tidal concentration 1.25-1.45%) and nitrous oxide to assess the effect of surgical stimulation on ventilation in humans. Tidal volume and respiratory timing were measured by pneumotachograph before and just after a standardized surgical skin incision. Surgical stimulation increased ventilation by increasing tidal volume, which increased progressively over the first five breaths after incision. The first breath after the stimulus was prolonged, but the timing of the subsequent breaths returned rapidly to the duration observed before incision. Ventilation increased from median 3.6 (quartiles 2.9, 4.3) to 5.4 (3.8, 7.0) litre min-1 (P < 0.01). The increased tidal volume was not associated consistently with shortening of inspiratory duration.
R W Sutherland; G B Drummond
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  76     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-08-21     Completed Date:  1996-08-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  777-9     Citation Subset:  IM    
Department of Anaesthetics, Royal Infirmary, Edinburgh.
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MeSH Terms
Anesthesia, Inhalation*
Anesthetics, Inhalation*
Middle Aged
Skin / surgery*
Tidal Volume
Reg. No./Substance:
0/Anesthetics, Inhalation; 13838-16-9/Enflurane

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