Document Detail

Effects of surfactant proteins SP-B and SP-C on dynamic and static mechanics of immature lungs.
MedLine Citation:
PMID:  9390954     Owner:  NLM     Status:  MEDLINE    
To investigate the effects of surfactant proteins B (SP-B) and C (SP-C) on lung mechanics, we compared tidal and static lung volumes of immature rabbits anesthetized with pentobarbital sodium and given reconstituted test surfactants (RTS). With a series of RTS having various SP-B concentrations (0-0.7%) but a fixed SP-C concentration (1.4%), both the tidal volume with 25-cmH2O insufflation pressure and the static volume deflated to 5-cmH2O airway pressure increased, significantly correlating with the SP-B concentration: the former increased from 6.5 to 26.0 ml/kg (mean), and the latter increased from 6.4 to 31.8 ml/kg. With another series of RTS having a fixed SP-B concentration (0.7%) but various SP-C concentrations (0-1.4%), the tidal volume increased from 5.1 to 24.8 ml/kg, significantly correlating with the SP-C concentration, whereas the static volume increased from 3.4 to 32.0 ml/kg, the ceiling value, in the presence of a minimal concentration of SP-C (0. 18%). In conclusion, certain doses of SP-B and SP-C were indispensable for optimizing dynamic lung mechanics; the static mechanics, however, required significantly less SP-C.
T Kobayashi; K Tashiro; K Yamamoto; S Nitta; S Ohmura; Y Suzuki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  83     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-02-10     Completed Date:  1998-02-10     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1849-56     Citation Subset:  IM    
Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Kanazawa University, Kanazawa 920, Japan.
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MeSH Terms
Animals, Newborn
Lung / drug effects,  growth & development,  physiology*
Proteolipids / pharmacology*
Pulmonary Alveoli / drug effects,  physiology
Pulmonary Surfactants / pharmacology*
Respiration, Artificial
Tidal Volume / drug effects
Reg. No./Substance:
0/Proteolipids; 0/Pulmonary Surfactants

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