| Effects of surfactant distribution and ventilation strategies on efficacy of exogenous surfactant. | |
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MedLine Citation:
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PMID: 9688746 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of both surfactant distribution patterns and ventilation strategies utilized after surfactant administration were assessed in lung-injured adult rabbits. Animals received 50 mg/kg surfactant via intratracheal instillation in volumes of either 4 or 2 ml/kg. A subset of animals from each treatment group was euthanized for evaluation of the exogenous surfactant distribution. The remaining animals were randomized into one of three ventilatory groups: group 1 [tidal volume (VT) of 10 ml/kg with 5 cmH2O positive end-expiratory pressure (PEEP)]; group 2 (VT of 5 ml/kg with 5 cmH2O PEEP); or group 3 (VT of 5 ml/kg with 9 cmH2O PEEP). Animals were ventilated and monitored for 3 h. Distribution of the surfactant was more uniform when it was delivered in the 4 ml/kg volume. When the distribution of surfactant was less uniform, arterial PO2 values were greater in groups 2 and 3 compared with group 1. Oxygenation differences among the different ventilation strategies were less marked in animals with the more uniform distribution pattern of surfactant (4 ml/kg). In both surfactant treatment groups, a high mortality was observed with the ventilation strategy used for group 3. We conclude that the distribution of exogenous surfactant affects the response to different ventilatory strategies in this model of acute lung injury. |
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Authors:
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C L Kerr; Y Ito; S E Manwell; R A Veldhuizen; L J Yao; L A McCaig; J F Lewis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 85 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-09-03 Completed Date: 1998-09-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 676-84 Citation Subset: IM |
Affiliation:
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Department of Physiology, St. Joseph's Health Centre, The University of Western Ontario, London, Ontario, Canada N6A 4V2. ckerr@julian.uwo.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Gas Analysis Cattle Hydrogen-Ion Concentration Oxygen / blood Oxygen Consumption / physiology Pulmonary Surfactants / metabolism*, pharmacology* Rabbits Respiration, Artificial* Respiratory Mechanics / physiology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Pulmonary Surfactants; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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