Document Detail

Effects of multivitamin/mineral supplementation on plasma levels of nutrients. Report No. 4 of the Italian-American clinical trial of nutritional supplements and age-related cataract.
MedLine Citation:
PMID:  19636163     Owner:  NLM     Status:  MEDLINE    
The use of multivitamin-mineral supplements has become increasingly common, but whether the use of such supplements improves micronutrient status remains still unclear. The objective of this report is to investigate how a long-term vitamin-mineral supplementation following the US Recommended Daily Intake (RDI) affected the plasma levels of selected nutrients in a subset (No. = 407) of participants in the Italian-American Clinical Trial of Nutritional Supplements and Age-related Cataract (CTNS). The CTNS was a double-blind, single centre, controlled clinical trial of 1020 participants aged 55-75 years randomized to a daily tablet of Centrum(R) or placebo. A representative sample of 40% of the 1020 subjects, whom plasma level of selected vitamins was determined at the baseline, was retested throughout the treatment period that averaged 9.0 +/- 2.4 years. Participants assigned to Centrum(R) showed a significant increase (p < 0.005) in mean/median plasma levels of vitamin E, beta-carotene, folate, and vitamin B12, and an improved riboflavin status when compared with participants assigned to placebo. Differences concerning vitamin C were statistically less relevant and those concerning vitamin A were at a borderline level. In the treated group the effect of supplementation on plasma levels of vitamins A, E, and C, and on the glutathione reductase activation coefficient was significantly higher in participants with lower nutritional status at baseline.
Giovanni Maraini; Sally L Williams; Robert D Sperduto; Frederick L Ferris; Roy C Milton; Traci E Clemons; Francesco Rosmini; Luigina Ferrigno
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Annali dell'Istituto superiore di sanità     Volume:  45     ISSN:  0021-2571     ISO Abbreviation:  Ann. Ist. Super. Sanita     Publication Date:  2009  
Date Detail:
Created Date:  2009-07-28     Completed Date:  2009-10-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7502520     Medline TA:  Ann Ist Super Sanita     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  119-27     Citation Subset:  IM    
Dipartimento di Scienze, Otorino-Odonto-Oftalmologiche e Cervico Facciali, Università degli Studi, Parma, Italy.
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MeSH Terms
Aging / physiology
Cataract / epidemiology,  prevention & control*
Dietary Supplements*
Drug Combinations
Follow-Up Studies
Italy / epidemiology
Middle Aged
Minerals / blood,  therapeutic use*
United States / epidemiology
Vitamins / blood,  therapeutic use*
Reg. No./Substance:
0/Drug Combinations; 0/Minerals; 0/Vitamins

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