Document Detail


Effects of supplemental dietary arginine, canola oil, and trace elements on cellular immune function in critically injured patients.
MedLine Citation:
PMID:  8828077     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dietary nutrients may have pharmacological value in modulating the immune system. We studied the effects of two enteral diets, which differed in their content of arginine, fat source, and select trace elements, on immune function in critically injured patients. Leukocytes were isolated from healthy volunteers and severely injured (ISS > 13) patients on the first, sixth, and tenth day of receiving either a standard diet or experimental diet. Monocytes were assayed for tumor necrosis factor, procoagulant activity, and prostaglandin E2 following endotoxin exposure. Neutrophil oxidant production and lymphocyte blastogenesis was assessed. Leukocyte function was uniformly depressed compared to normal patients on day 1. The response of leukocytes from patients receiving experimental diet improved or "normalized" by day 6, while remaining depressed in patients receiving standard diet. Dietary nutrient modification can effect cellular immune responses to inflammatory stimuli in severely injured patients.
Authors:
C Mendez; G J Jurkovich; M H Wener; I Garcia; M Mays; R V Maier
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Publication Detail:
Type:  Clinical Trial; In Vitro; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Shock (Augusta, Ga.)     Volume:  6     ISSN:  1073-2322     ISO Abbreviation:  Shock     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-12-13     Completed Date:  1996-12-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9421564     Medline TA:  Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  7-12     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of Washington, Harborview Medical Center, Seattle 98104, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Arginine*
Critical Illness / therapy*
Dinoprostone / blood
Endotoxins
Enteral Nutrition
Factor VIII / analysis
Fatty Acids, Monounsaturated*
Food, Fortified*
Humans
Lipopolysaccharides / pharmacology
Lymphocyte Activation*
Middle Aged
Monocytes / drug effects,  immunology
Neutrophils / physiology
Prospective Studies
Reference Values
Severity of Illness Index
Time Factors
Trace Elements*
Trauma Centers
Tumor Necrosis Factor-alpha / analysis
Wounds and Injuries / surgery
Grant Support
ID/Acronym/Agency:
GM-07037/GM/NIGMS NIH HHS; GM-45873/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Endotoxins; 0/Fatty Acids, Monounsaturated; 0/Lipopolysaccharides; 0/Trace Elements; 0/Tumor Necrosis Factor-alpha; 120962-03-0/canola oil; 363-24-6/Dinoprostone; 74-79-3/Arginine; 9001-27-8/Factor VIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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