Document Detail

Effects of sulphur-containing compounds on plasma redox status in muscle-damaging exercise.
MedLine Citation:
PMID:  20034232     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to compare effects of three-day N-acetylcysteine, alpha-lipoic acid or taurine administration on plasma antioxidant status and oxidative damage markers in healthy men after performing muscle-damaging exercise. Fifty-five healthy and trained men were randomly assigned to N-acetylcysteine (NAC, 1.8 g/day, 3 days), alpha-lipoic acid (ALA, 1.2 g/day, 3 days), taurine (TAU, 3 g/day, 3 days) and control group (CON), and exposed to intense resistance exercise. The resistance exercise induced the muscle damage which was observed by significant increase in total creatine kinase (CK) activity at 24 h rest. The administration of NAC and ALA significantly elevated the resting or/and postexercise plasma total antioxidant status (TAS) and total thiols (TT). Uric acid (UA) concentration was decreased by NAC, ALA and TAU at 24 h rest compared with CON. The plasma lipid peroxidation (TBARS) and protein carbonylation (PC) were considerably reduced by NAC and ALA administration at rest and after exercise. TAU did not have any influence on TAS, TT, TBARS and PC levels. Our study has shown that three-day oral N-acetylcysteine and alpha-lipoic acid administration enhanced plasma total antioxidant status and attenuated oxidative damage whereas taurine did not demonstrate any antioxidant action in healthy men after performing a single muscle-damaging exercise.
Agnieszka Zembron-Lacny; Joanna Ostapiuk; Kazimierz Szyszka
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Chinese journal of physiology     Volume:  52     ISSN:  0304-4920     ISO Abbreviation:  Chin J Physiol     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-12-25     Completed Date:  2010-01-28     Revised Date:  2010-03-29    
Medline Journal Info:
Nlm Unique ID:  7804502     Medline TA:  Chin J Physiol     Country:  China (Republic : 1949- )    
Other Details:
Languages:  eng     Pagination:  289-94     Citation Subset:  IM    
Department of Biochemistry and Sport Medicine, Faculty of Physical Culture Gorzow Wlkp., University of Physical Education, Poznan, Poland.
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MeSH Terms
Acetylcysteine / pharmacology*
Antioxidants / metabolism*
Dose-Response Relationship, Drug
Exercise / physiology*
Protein Carbonylation / drug effects
Resistance Training*
Sulfhydryl Compounds / blood
Taurine / pharmacology*
Thiobarbituric Acid Reactive Substances / metabolism
Thioctic Acid / pharmacology*
Uric Acid / blood
Young Adult
Reg. No./Substance:
0/Antioxidants; 0/Sulfhydryl Compounds; 0/Thiobarbituric Acid Reactive Substances; 107-35-7/Taurine; 616-91-1/Acetylcysteine; 62-46-4/Thioctic Acid; 69-93-2/Uric Acid
Erratum In:
Chin J Physiol. 2009 Dec 31;52(6):455

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