| Effects of sulphur-containing compounds on plasma redox status in muscle-damaging exercise. | |
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MedLine Citation:
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PMID: 20034232 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the study was to compare effects of three-day N-acetylcysteine, alpha-lipoic acid or taurine administration on plasma antioxidant status and oxidative damage markers in healthy men after performing muscle-damaging exercise. Fifty-five healthy and trained men were randomly assigned to N-acetylcysteine (NAC, 1.8 g/day, 3 days), alpha-lipoic acid (ALA, 1.2 g/day, 3 days), taurine (TAU, 3 g/day, 3 days) and control group (CON), and exposed to intense resistance exercise. The resistance exercise induced the muscle damage which was observed by significant increase in total creatine kinase (CK) activity at 24 h rest. The administration of NAC and ALA significantly elevated the resting or/and postexercise plasma total antioxidant status (TAS) and total thiols (TT). Uric acid (UA) concentration was decreased by NAC, ALA and TAU at 24 h rest compared with CON. The plasma lipid peroxidation (TBARS) and protein carbonylation (PC) were considerably reduced by NAC and ALA administration at rest and after exercise. TAU did not have any influence on TAS, TT, TBARS and PC levels. Our study has shown that three-day oral N-acetylcysteine and alpha-lipoic acid administration enhanced plasma total antioxidant status and attenuated oxidative damage whereas taurine did not demonstrate any antioxidant action in healthy men after performing a single muscle-damaging exercise. |
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Authors:
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Agnieszka Zembron-Lacny; Joanna Ostapiuk; Kazimierz Szyszka |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Chinese journal of physiology Volume: 52 ISSN: 0304-4920 ISO Abbreviation: Chin J Physiol Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-12-25 Completed Date: 2010-01-28 Revised Date: 2010-03-29 |
Medline Journal Info:
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Nlm Unique ID: 7804502 Medline TA: Chin J Physiol Country: China (Republic : 1949- ) |
Other Details:
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Languages: eng Pagination: 289-94 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Sport Medicine, Faculty of Physical Culture Gorzow Wlkp., University of Physical Education, Poznan, Poland. biochem@awf-gorzow.edu.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcysteine
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pharmacology* Antioxidants / metabolism* Dose-Response Relationship, Drug Exercise / physiology* Humans Male Oxidation-Reduction Protein Carbonylation / drug effects Resistance Training* Sulfhydryl Compounds / blood Taurine / pharmacology* Thiobarbituric Acid Reactive Substances / metabolism Thioctic Acid / pharmacology* Uric Acid / blood Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Sulfhydryl Compounds; 0/Thiobarbituric Acid Reactive Substances; 107-35-7/Taurine; 616-91-1/Acetylcysteine; 62-46-4/Thioctic Acid; 69-93-2/Uric Acid |
| Comments/Corrections | |
Erratum In:
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Chin J Physiol. 2009 Dec 31;52(6):455 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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