Document Detail

Effects of sucralfate on mucositis during and following radiotherapy of malignancies in the head and neck region. A double-blind placebo-controlled study.
MedLine Citation:
PMID:  7718260     Owner:  NLM     Status:  MEDLINE    
Radiotherapy of head and neck malignancies is accompanied by oral discomforts, such as epithelitis, pain and functional impairment. This can lead to chronic sequalae with subjective distress such as loss of taste and xerostomia and pronounced decrease in quality of life. Thus, the need to reduce the mucosal damage following radiotherapy is obvious. Therefore, we investigated the possible ability of sucralfate, an aluminium hydroxide complex of sulphated sucrose used in the treatment of gastric ulcer, in preventing oral discomfort in patients treated with curative intent for malignancies in the head and neck region. The study was double-blind, placebo-controlled and randomized and included 50 consecutive patients. The study demonstrated that the proportion of patients with severe mucosal reactions was significantly lower in the sucralfate group than in the placebo group.
L Franzén; R Henriksson; B Littbrand; B Zackrisson
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta oncologica (Stockholm, Sweden)     Volume:  34     ISSN:  0284-186X     ISO Abbreviation:  Acta Oncol     Publication Date:  1995  
Date Detail:
Created Date:  1995-05-25     Completed Date:  1995-05-25     Revised Date:  2009-05-12    
Medline Journal Info:
Nlm Unique ID:  8709065     Medline TA:  Acta Oncol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  219-23     Citation Subset:  IM    
Department of Oncology, Umeå University, Sweden.
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MeSH Terms
Combined Modality Therapy
Double-Blind Method
Head and Neck Neoplasms / radiotherapy*
Mouth Mucosa / drug effects,  radiation effects
Stomatitis / drug therapy*
Sucralfate / therapeutic use*
Reg. No./Substance:

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