| Effects of sucralfate on mucositis during and following radiotherapy of malignancies in the head and neck region. A double-blind placebo-controlled study. | |
| | |
MedLine Citation:
|
PMID: 7718260 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Radiotherapy of head and neck malignancies is accompanied by oral discomforts, such as epithelitis, pain and functional impairment. This can lead to chronic sequalae with subjective distress such as loss of taste and xerostomia and pronounced decrease in quality of life. Thus, the need to reduce the mucosal damage following radiotherapy is obvious. Therefore, we investigated the possible ability of sucralfate, an aluminium hydroxide complex of sulphated sucrose used in the treatment of gastric ulcer, in preventing oral discomfort in patients treated with curative intent for malignancies in the head and neck region. The study was double-blind, placebo-controlled and randomized and included 50 consecutive patients. The study demonstrated that the proportion of patients with severe mucosal reactions was significantly lower in the sucralfate group than in the placebo group. |
| | |
Authors:
|
L Franzén; R Henriksson; B Littbrand; B Zackrisson |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Acta oncologica (Stockholm, Sweden) Volume: 34 ISSN: 0284-186X ISO Abbreviation: Acta Oncol Publication Date: 1995 |
Date Detail:
|
Created Date: 1995-05-25 Completed Date: 1995-05-25 Revised Date: 2009-05-12 |
Medline Journal Info:
|
Nlm Unique ID: 8709065 Medline TA: Acta Oncol Country: NORWAY |
Other Details:
|
Languages: eng Pagination: 219-23 Citation Subset: IM |
Affiliation:
|
Department of Oncology, Umeå University, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Combined Modality Therapy Double-Blind Method Head and Neck Neoplasms / radiotherapy* Humans Mouth Mucosa / drug effects, radiation effects Stomatitis / drug therapy* Sucralfate / therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
54182-58-0/Sucralfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Azidothymidine (AZT) as a potential modifier of radiation response in vitro.
Next Document: Influence of boost technique (external beam radiotherapy or brachytherapy) on the outcome of patient...