| Effects of sucralfate and its components on indomethacin-induced damage to cultured rabbit gastric mucosal cells. | |
MedLine Citation:
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PMID: 9116328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the effects of sucralfate and its components on indomethacin-induced damage to cultured rabbit gastric mucosal cells. Cell viability was assessed by colorimetric and dye exclusion methods. Exposure of mucosal cells to indomethacin at 50 and 500 microM for 4 hr significantly reduced their viability, the viability loss being bout 40% and about 90% respectively. Pretreatment of the cells with sucralfate for 30 min prevented the reduction in viability caused by 50 microM indomethacin in a dose-related manner. Furthermore, sucralfate also significantly protected mucosal cells against severe damage caused by 500 microM indomethacin. However, neither sucrose octasulfate nor Al(OH)3. (the components of sucralfate) significantly prevented the reduction in viability caused by 50 and 500 microM indomethacin, although these components tended to inhibit the viability loss. When mucosal cells were incubated with sucralfate or its components for 4 hr, the drugs did not affect the cell viability. These results indicate that sucralfate directly protects gastric mucosal cells against cell damage caused by indomethacin, and that the protective effect of sucralfate might be expressed as a synergistic action of its components. |
Authors:
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S Takahashi; S Okabe |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society Volume: 47 ISSN: 0867-5910 ISO Abbreviation: J. Physiol. Pharmacol. Publication Date: 1996 Dec |
Date Detail:
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Created Date: 1997-04-24 Completed Date: 1997-04-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9114501 Medline TA: J Physiol Pharmacol Country: POLAND |
Other Details:
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Languages: eng Pagination: 611-9 Citation Subset: IM |
Affiliation:
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Department of Applied Pharmacology, Kyoto Pharmaceutical University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aluminum Hydroxide
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pharmacology Animals Cell Survival / drug effects Cells, Cultured / drug effects Gastric Mucosa / drug effects*, pathology Gastrointestinal Agents / pharmacology* Indomethacin / toxicity* Male Rabbits Sucralfate / pharmacology* Sucrose / analogs & derivatives, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Gastrointestinal Agents; 21645-51-2/Aluminum Hydroxide; 53-86-1/Indomethacin; 54182-58-0/Sucralfate; 57-50-1/Sucrose; 57680-56-5/sucrose octasulfate |
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