Document Detail


Effects of successive intrastriatal methylmercury administrations on dopaminergic system.
MedLine Citation:
PMID:  12742365     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study was carried out in order to determine the effects of intrastriatal administration of different doses (40 microM, 400 microM, and 4mM) of methylmercury (MeHg) on dopaminergic system of rat striatum. Experiments were performed in conscious and freely moving rats using brain microdialysis coupled with liquid chromatography. Intrastriatal administration of MeHg produced significant increases in dopamine (DA) striatal levels (907+/-7%, 1870+/-319%, and 7971+/-534% for the doses of 40, 400 microM, and 4mM, with respect to basal). The increase in DA levels was associated with significant decreases in extracellular levels of its main metabolites dihydroxyphenylacetic acid (DOPAC) and homovallinic acid (HVA) (65.0+/-3.0% and 52.2+/-1.3%, respectively) using the dose of 4mM MeHg, whereas nonsignificant changes in metabolite levels were observed with the doses of 40 and 400 microM MeHg. A second infusion of 4mM MeHg 24h after first infusion also produced a rise of DA levels, but this increase was very small as compared with that produced by first infusion (7971+/-534% versus 985+/-186%). This second infusion of 4mM MeHg also decreased DOPAC and HVA levels, but this decrease was not significant as compared with that observed after first infusion (65.0+/-3.0% and 52.2+/-1.3% versus 62.4+/-5.2% and 63.4+/-7.4%, respectively). We discuss these effects based on a stimulated DA release and/or a decreased DA intraneuronal degradation.
Authors:
L R F Faro; R Durán; J L M Do Nascimento; D Perez-Vences; M Alfonso
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Ecotoxicology and environmental safety     Volume:  55     ISSN:  0147-6513     ISO Abbreviation:  Ecotoxicol. Environ. Saf.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-05-13     Completed Date:  2003-09-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7805381     Medline TA:  Ecotoxicol Environ Saf     Country:  United States    
Other Details:
Languages:  eng     Pagination:  173-7     Citation Subset:  IM    
Affiliation:
Departamento de Fisiologia, Centro de Ciências Biológicas, UFPA, PA, Belém, Brazil.
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MeSH Terms
Descriptor/Qualifier:
3,4-Dihydroxyphenylacetic Acid / metabolism
Animals
Chromatography, High Pressure Liquid
Dopamine / metabolism,  physiology*
Extracellular Space / drug effects,  metabolism
Female
Homovanillic Acid / metabolism
Methylmercury Compounds / administration & dosage,  toxicity*
Microdialysis
Microinjections
Neostriatum / drug effects,  metabolism,  physiology*
Neurotransmitter Agents / metabolism
Rats
Rats, Sprague-Dawley
Synaptic Transmission / drug effects
Chemical
Reg. No./Substance:
0/Methylmercury Compounds; 0/Neurotransmitter Agents; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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