Document Detail

Effects of subtoxic concentrations of benzoyl peroxide on cell lipid metabolism.
MedLine Citation:
PMID:  15514964     Owner:  NLM     Status:  MEDLINE    
Benzoyl peroxide (BP), a tumor promoter, has been shown to cause free-radical-induced lipid peroxidation and membrane damage at toxic concentrations. However, its effects on lipid metabolism at concentrations that were not overtly toxic have not been investigated. The purpose of the current study was to examine the effects of BP and its final degradation product, benzoic acid (BA), on lipid metabolism. Two cell lines, hamster cheek pouch (HCP) and human monocytes (THP-1), were used to determine the effects of BP, BA, and BP combined with FeCl2 on cell lipid metabolism. Cells were exposed to BP and 14C acetate for 24 h, or cells with prelabeled lipids were harvested, and the lipids were extracted and separated with the use of thin-layer chromatography. Lipid metabolism of some neutral lipids such as triglycerides was altered for both cell types in response to BP. Also, cholesterol content was reduced in THP-1 cells and a phospholipid, phosphatidylethanolamine (PE), was reduced in HCP cells. The final degradation product of BP, BA, failed to elicit any response in lipid metabolism. Subtoxic concentrations of BP induced changes in neutral lipids such as triglycerides and cholesterol. The metabolism of major phospholipids except PE remained unchanged. The effects were related to BP and its degradation and varied with the cell type.
R Datar; Fredrick A Rueggeberg; G B Caughman; John C Wataha; Jill Lewis; G S Schuster
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biomedical materials research. Part A     Volume:  71     ISSN:  1549-3296     ISO Abbreviation:  -     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-19     Completed Date:  2005-05-03     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  101234237     Medline TA:  J Biomed Mater Res A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  685-92     Citation Subset:  IM    
Department of Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, 1120 15th Street, Augusta, Georgia 30912, USA.
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MeSH Terms
Benzoic Acid / pharmacology
Benzoyl Peroxide / pharmacology*
Cell Count
Cell Line
Cell Membrane Permeability / drug effects
Cell Proliferation / drug effects
Epithelial Cells / drug effects,  metabolism
Keratolytic Agents / pharmacology*
Lipid Metabolism*
Monocytes / drug effects,  metabolism
Reg. No./Substance:
0/Keratolytic Agents; 65-85-0/Benzoic Acid; 94-36-0/Benzoyl Peroxide

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