Document Detail

Effects of substitution of N-terminal amino acid of glucagon-like peptide-1 (7-36) amide on food intake of the neonatal chick.
MedLine Citation:
PMID:  10619374     Owner:  NLM     Status:  MEDLINE    
Glucagon-like peptide-1 (GLP-1), a member of glucagon superfamily, is synthesized from a large precursor, preproglucagon, and has been postulated to be a novel incretin. Recently, it was reported that central administration of GLP-1 (7-36) amide decreased food intake in rats and chickens. Generally, the amino acid sequences of the glucagon superfamily members except for gastric inhibitory peptide and growth hormone-releasing factor are identical at N-terminal histidine. It is well known that the GLP-1 receptor is highly specific for GLP-1 and does not bind other peptides of the glucagon superfamily. The aim of this study was to elucidate whether central injection of substituted GLP-1 in which N-terminal histidine of mammalian GLP-1 (7-36) amide was replaced with tyrosine, inhibits food intake in the chick. Intracerebroventricular administration of substituted GLP-1 inhibits food intake in the chick, although the effect of substituted GLP-1 was 11 to 13 fold less than that of mammalian GLP-1 (7-36) amide. These results indicate that N-terminal histidine of GLP-1 (7-36) amide is important for efficacy, but not essential for its bioactivity.
T Bungo; M Shimojo; Y Masuda; N Saito; K Sugahara; S Hasegawa; M Furuse
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  65     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1999  
Date Detail:
Created Date:  2000-01-19     Completed Date:  2000-01-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  PL295-9     Citation Subset:  IM    
Division of Animal and Marine Bioresources Science, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Amino Acid Sequence
Amino Acid Substitution*
Animals, Newborn
Eating / drug effects*
Glucagon / metabolism,  pharmacology*
Glucagon-Like Peptide 1
Glucagon-Like Peptides
Histidine / metabolism
Injections, Intraventricular
Molecular Sequence Data
Peptide Fragments / metabolism,  pharmacology*
Protein Precursors / metabolism,  pharmacology*
Structure-Activity Relationship
Tyrosine / metabolism
Reg. No./Substance:
0/Peptide Fragments; 0/Protein Precursors; 119637-73-9/glucagon-like peptide 1 (7-36)amide; 55520-40-6/Tyrosine; 62340-29-8/Glucagon-Like Peptides; 71-00-1/Histidine; 89750-14-1/Glucagon-Like Peptide 1; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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