Document Detail


Effects of subcutaneous recombinant human erythropoietin in patients on continuous ambulatory peritoneal dialysis.
MedLine Citation:
PMID:  8399659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The use of recombinant human erythropoietin (rHuEPO) has revolutionized the treatment of renal anemia, but the dose regimens, the optimal frequency, and the effects on other target organs like the central nervous systems (CNS) are still under discussion. We designed a prospective, ongoing study with 10 stable continuous ambulatory peritoneal dialysis (CAPD) patients (6 males, 4 females; mean age 64.4 +/- 7.8 years), with a pretreatment hemoglobin (Hb) < 7.0 g% and requiring regular blood transfusions. Seven patients were treated with 4000 U rHuEPO once weekly (Eritrogen, Boehringer Mannheim), 2 patients received 4000 U every 5 and 8 days, and the last one 4000 U every 10 days. The target hematocrit was 33% and Hb 10.0 g%. The CNS activity was recorded as visual (VEP), brainstem (BAER), and somatosensory (SEP)-evoked potentials. The mean Hb concentration increased from 6.9 +/- 1.2 g% to 10.3 +/- 1.6 g% (p < 0.001) over 8 weeks. There were no significant changes in urea, creatinine, and potassium levels, and urine output. rHuEPO induced a decrease in latency of P100 VEP, in the four main components of BAER, and in the P27-N35 intertime of SEP. Parallel to the improvement of red cell indices, patients experienced a dramatic improvement in well-being. The subcutaneous administration of a single vial of rHuEPO is safe, convenient, and inexpensive in CAPD. The role of rHuEPO treatment in improving the electrophysiological brain function in uremic and anemic patients remains to be studied and may not necessarily be based on improved cerebral oxygenation.
Authors:
B Di Paolo; A Marini; B Fiederling; L Di Liberato; P Santarelli; S Bucciarelli; S Stuard; L Paolantonio; A Albertazzi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis     Volume:  13 Suppl 2     ISSN:  0896-8608     ISO Abbreviation:  Perit Dial Int     Publication Date:  1993  
Date Detail:
Created Date:  1993-11-01     Completed Date:  1993-11-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8904033     Medline TA:  Perit Dial Int     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  S538-40     Citation Subset:  IM    
Affiliation:
Department of Nephrology and Dialysis, University of Chieti, Italy.
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MeSH Terms
Descriptor/Qualifier:
Aged
Anemia / blood,  etiology,  physiopathology,  therapy
Erythropoietin / administration & dosage*
Evoked Potentials
Female
Hematocrit
Hemoglobins / analysis
Humans
Injections, Subcutaneous
Male
Middle Aged
Peritoneal Dialysis, Continuous Ambulatory*
Prospective Studies
Recombinant Proteins / administration & dosage
Uremia / complications,  therapy
Chemical
Reg. No./Substance:
0/Hemoglobins; 0/Recombinant Proteins; 11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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