| Effects of subcutaneous methadone, morphine, buprenorphine or saline on thermal and pressure thresholds in cats. | |
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MedLine Citation:
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PMID: 17083457 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study compared pressure and thermal thresholds after administration of three opioids in eight cats. Pressure stimulation was performed via a bracelet taped around the forearm. Three ball-bearings were advanced against the forearm by inflation of a modified blood pressure bladder. Pressure in the cuff was recorded at the end point (leg shake and head turn). Thermal threshold was tested as previously reported using a heated probe held against the thorax [Dixon et al. (2002) Research in Veterinary Science, 72, 205]. After baseline recordings, each cat received subcutaneous methadone 0.2 mg/kg, morphine 0.2 mg/kg, buprenorphine 0.02 mg/kg or saline 0.3 mL in a four period cross-over study. Measurements were made at 15, 30, 45 min and 1, 2, 3, 4, 8, 12 and 24 h after the injection. Data were analysed by anova (P<0.05). There were no significant changes in thresholds after saline. Thermal threshold increased at 45 min after buprenorphine (maximum 2.8+/-3 degrees C), 1-3 h after methadone (maximum 3.4+/-1.9 degrees C) and 45 min to 1 h (maximum 3.4+/-2 degrees C) after morphine. Pressure threshold increased 30-45 min (maximum 238+/-206 mmHg) after buprenorphine, 45-60 min after methadone (maximum 255+/-232 mmHg) and 45-60 min and 3-6 h (maximum 255+/-232 mmHg) after morphine. Morphine provided the best analgesia, and methadone appears a promising alternative. Buprenorphines limited effect was probably related to the subcutaneous route of administration. Previously, buprenorphine has produced much greater effects when given by other routes. |
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Authors:
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P V M Steagall; P Carnicelli; P M Taylor; S P L Luna; M Dixon; T H Ferreira |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of veterinary pharmacology and therapeutics Volume: 29 ISSN: 0140-7783 ISO Abbreviation: J. Vet. Pharmacol. Ther. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-11-06 Completed Date: 2007-01-19 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7910920 Medline TA: J Vet Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 531-7 Citation Subset: IM |
Affiliation:
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Faculty of Veterinary Medicine and Animal Science, FMVZ, Unesp, Botucatu, SP, Brazil. pvms2001@yahoo.com.br |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics, Opioid
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administration & dosage,
pharmacology* Animals Buprenorphine / administration & dosage, pharmacology Cats Female Hot Temperature Injections, Subcutaneous / veterinary Male Methadone / administration & dosage, pharmacology Morphine / administration & dosage, pharmacology Pain / prevention & control, veterinary* Pain Measurement / drug effects, veterinary* Pressure |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 52485-79-7/Buprenorphine; 57-27-2/Morphine; 76-99-3/Methadone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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