Document Detail


Effects of subcutaneous methadone, morphine, buprenorphine or saline on thermal and pressure thresholds in cats.
MedLine Citation:
PMID:  17083457     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study compared pressure and thermal thresholds after administration of three opioids in eight cats. Pressure stimulation was performed via a bracelet taped around the forearm. Three ball-bearings were advanced against the forearm by inflation of a modified blood pressure bladder. Pressure in the cuff was recorded at the end point (leg shake and head turn). Thermal threshold was tested as previously reported using a heated probe held against the thorax [Dixon et al. (2002) Research in Veterinary Science, 72, 205]. After baseline recordings, each cat received subcutaneous methadone 0.2 mg/kg, morphine 0.2 mg/kg, buprenorphine 0.02 mg/kg or saline 0.3 mL in a four period cross-over study. Measurements were made at 15, 30, 45 min and 1, 2, 3, 4, 8, 12 and 24 h after the injection. Data were analysed by anova (P<0.05). There were no significant changes in thresholds after saline. Thermal threshold increased at 45 min after buprenorphine (maximum 2.8+/-3 degrees C), 1-3 h after methadone (maximum 3.4+/-1.9 degrees C) and 45 min to 1 h (maximum 3.4+/-2 degrees C) after morphine. Pressure threshold increased 30-45 min (maximum 238+/-206 mmHg) after buprenorphine, 45-60 min after methadone (maximum 255+/-232 mmHg) and 45-60 min and 3-6 h (maximum 255+/-232 mmHg) after morphine. Morphine provided the best analgesia, and methadone appears a promising alternative. Buprenorphines limited effect was probably related to the subcutaneous route of administration. Previously, buprenorphine has produced much greater effects when given by other routes.
Authors:
P V M Steagall; P Carnicelli; P M Taylor; S P L Luna; M Dixon; T H Ferreira
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of veterinary pharmacology and therapeutics     Volume:  29     ISSN:  0140-7783     ISO Abbreviation:  J. Vet. Pharmacol. Ther.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-06     Completed Date:  2007-01-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7910920     Medline TA:  J Vet Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  531-7     Citation Subset:  IM    
Affiliation:
Faculty of Veterinary Medicine and Animal Science, FMVZ, Unesp, Botucatu, SP, Brazil. pvms2001@yahoo.com.br
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MeSH Terms
Descriptor/Qualifier:
Analgesics, Opioid / administration & dosage,  pharmacology*
Animals
Buprenorphine / administration & dosage,  pharmacology
Cats
Female
Hot Temperature
Injections, Subcutaneous / veterinary
Male
Methadone / administration & dosage,  pharmacology
Morphine / administration & dosage,  pharmacology
Pain / prevention & control,  veterinary*
Pain Measurement / drug effects,  veterinary*
Pressure
Chemical
Reg. No./Substance:
0/Analgesics, Opioid; 52485-79-7/Buprenorphine; 57-27-2/Morphine; 76-99-3/Methadone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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