Document Detail

Effects of subchronic exposure to Caramel Colour III on the immune system in mice.
MedLine Citation:
PMID:  8132168     Owner:  NLM     Status:  MEDLINE    
Administration of Caramel Colour III is associated with lymphopenia in laboratory animals, especially if the animals are fed a vitamin B6-deficient diet. Recently, functional immunological alterations in rats exposed to Caramel Colour III have been reported. The component of Caramel Colour III that is responsible for the immunological effects has been shown to be 2-acetyl-4-tetrahydroxybutyl imidazole (THI). In the present study, female Balb/c mice fed a diet with a relatively high vitamin B6 content were exposed to 2 or 10% of a commercial Caramel Colour III preparation with a low THI content (less than 25 ppm) in the drinking water for 9 wk. Although this treatment did not induce a lymphopenia in the exposed mice, flow cytometric analysis of lymphocyte subpopulations demonstrated reductions in the CD4+ and CD8+ cell populations. In addition, the proliferative response of spleen cells to B and T cell mitogens was significantly reduced in the mice exposed to 2% Caramel Colour III. No changes were observed in natural killer cell activity or in the humoral antibody response to a viral antigen. The results indicate that Caramel Colour III that meets the specified limit of less than 25 mg THI/kg may, nevertheless, interfere with the lymphoid system in mice with an adequate vitamin B6 status.
A Thuvander; A Oskarsson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  32     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-04-19     Completed Date:  1994-04-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  7-13     Citation Subset:  IM    
National Food Administration, Uppsala, Sweden.
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MeSH Terms
Antibodies, Viral / blood
Antigens, Viral / immunology
Food Coloring Agents / administration & dosage,  pharmacology*,  toxicity
Imidazoles / administration & dosage,  toxicity
Immunity / drug effects*
Immunosuppressive Agents
Interleukin-2 / metabolism
Killer Cells, Natural / immunology
Lymphocyte Activation / drug effects
Lymphopenia / chemically induced
Mice, Inbred BALB C
Organic Chemicals
Orthomyxoviridae / immunology
Pyridoxine / administration & dosage
Reg. No./Substance:
0/Antibodies, Viral; 0/Antigens, Viral; 0/Carbohydrates; 0/Food Coloring Agents; 0/Imidazoles; 0/Immunosuppressive Agents; 0/Interleukin-2; 0/Organic Chemicals; 65-23-6/Pyridoxine; 8028-89-5/caramel; 94944-70-4/2-acetyl-4(5)-tetrahydroxybutylimidazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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