Document Detail


Effects of structural modifications of daunorubicin on in vitro antileukemic activity.
MedLine Citation:
PMID:  23225426     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
MATERIALS AND METHODS: The experiments were performed on human acute lymphoblastic leukemia MOLT-4 cells and human acute myeloblastic leukemia ML-1 cells. The research was conducted using the spectrophotometric 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) assay and the electronic Beckman-Coulter method.
RESULTS: Temporary changes in the leukemia cell viability, size and count were found. The antileukemic activities of the new DAU analogs were weaker than that of daunorubicin. MOLT-4 cells were more sensitive than ML-1 cells to the action of all agents. Among the formamidinodaunorubicins, DAUFmor appeared to be more active in ML-1 cells than DAUFhex, but there were not differences between the analyzed values in MOLT-4 cells.
CONCLUSION: The structural modifications of daunorubicin were responsible for the different antileukemic potentials of the two formamidinodaunorubicins.
Authors:
Marta Stojak; Lidia Mazur; Malgorzata Opydo-Chanek; Malgorzata Lukawska; Irena Oszczapowicz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  32     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  5271-7     Citation Subset:  IM    
Affiliation:
D.Sc., Department of Experimental Hematology, Jagiellonian University, Gronostajowa 9, 30-387 Cracow, Poland. lidia.mazur@uj.edu.pl.
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