| Effects of structural modifications of daunorubicin on in vitro antileukemic activity. | |
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MedLine Citation:
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PMID: 23225426 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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MATERIALS AND METHODS: The experiments were performed on human acute lymphoblastic leukemia MOLT-4 cells and human acute myeloblastic leukemia ML-1 cells. The research was conducted using the spectrophotometric 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) assay and the electronic Beckman-Coulter method. RESULTS: Temporary changes in the leukemia cell viability, size and count were found. The antileukemic activities of the new DAU analogs were weaker than that of daunorubicin. MOLT-4 cells were more sensitive than ML-1 cells to the action of all agents. Among the formamidinodaunorubicins, DAUFmor appeared to be more active in ML-1 cells than DAUFhex, but there were not differences between the analyzed values in MOLT-4 cells. CONCLUSION: The structural modifications of daunorubicin were responsible for the different antileukemic potentials of the two formamidinodaunorubicins. |
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Authors:
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Marta Stojak; Lidia Mazur; Malgorzata Opydo-Chanek; Malgorzata Lukawska; Irena Oszczapowicz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anticancer research Volume: 32 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 5271-7 Citation Subset: IM |
Affiliation:
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D.Sc., Department of Experimental Hematology, Jagiellonian University, Gronostajowa 9, 30-387 Cracow, Poland. lidia.mazur@uj.edu.pl. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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