Document Detail

Effects of stretch or distention on phenylephrine-induced constriction of human coronary artery bypass grafts.
MedLine Citation:
PMID:  11748519     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the effects of grafting saphenous veins into the arterial circulation and to compare the responsiveness of saphenous veins and mammary arteries to vasoconstrictors (phenylephrine or potassium) and a vasodilator (the calcium antagonist isradipine). DESIGN: Prospective, controlled, in vitro study. SETTING: Laboratory facility in a university teaching hospital. PARTICIPANTS: Small excess segments of internal mammary arteries or saphenous veins obtained from patients undergoing coronary artery bypass graft surgery. INTERVENTIONS: Vessel segments were cut into rings to measure isometric tension development in isolated tissue chambers. The law of LaPlace for a cylinder was applied to determine tensions in vitro corresponding with arterial or venous tensions in vivo or distending pressures ex vivo. MEASUREMENTS AND MAIN RESULTS: Stretching saphenous vein rings from venous to arterial tensions reduced maximal phenylephrine-induced constriction but did not alter their dose response to phenylephrine, potassium, or isradipine. At arterial tensions, potassium, but not phenylephrine, was more potent in constricting mammary artery than saphenous vein; isradipine was more potent as a vasodilator of potassium-constricted mammary artery than saphenous vein. Maximal phenylephrine-induced or potassium-induced constriction was no different for either vessel at arterial tensions; however, prior distention of veins to tensions corresponding with pressures of 200 or 300 mmHg significantly (p < 0.01, Dunnett's test) reduced subsequent constriction. CONCLUSION: Phenylephrine may be more likely to constrict native internal mammary arteries than distended autogenous saphenous vein grafts in vivo because high-pressure distention of veins markedly inhibits their vasoreactivity.
W W Wendling; L J Krasner; S C Cooper; D Chen; C Harakal; V P Addonizio; N W Brister; C Carlsson
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of cardiothoracic and vascular anesthesia     Volume:  15     ISSN:  1053-0770     ISO Abbreviation:  J. Cardiothorac. Vasc. Anesth.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-18     Completed Date:  2002-01-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9110208     Medline TA:  J Cardiothorac Vasc Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  717-22     Citation Subset:  IM    
Copyright Information:
Copyright 2001 by W.B. Saunders Company
Department of Anesthesiology, Section of Cardiac and Thoracic Surgery, Temple University Hospital, 3401 North Broad Street, Philadelphia, PA 19140, USA..
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MeSH Terms
Coronary Artery Bypass*
Dose-Response Relationship, Drug
Isradipine / pharmacology
Mammary Arteries / drug effects*,  physiology,  transplantation
Phenylephrine / pharmacology*
Potassium / pharmacology
Saphenous Vein / drug effects*,  physiology,  transplantation
Stress, Mechanical
Vasoconstriction / drug effects,  physiology*
Vasoconstrictor Agents / pharmacology*
Vasodilator Agents / pharmacology
Grant Support
Reg. No./Substance:
0/Vasoconstrictor Agents; 0/Vasodilator Agents; 59-42-7/Phenylephrine; 7440-09-7/Potassium; 75695-93-1/Isradipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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