Document Detail


Effects of strength training on muscle hypertrophy and muscle cell disruption in older men.
MedLine Citation:
PMID:  7591389     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine whether a total body, heavy resistance, strength training (ST) program can significantly increase muscle strength and hypertrophy without muscle cell disruption and soreness in older men, 35 sedentary male subjects between the ages of 50 and 69 years of age (60 +/- 5, mean +/- SD) were studied. Twelve served as inactive controls. Muscular strength, cross-sectional muscle area, serum creatine kinase (CK) activity and perceived soreness were assessed before and after a 16 wk heavy resistance ST program. The ST program resulted in a 43% increase in muscular strength (p < 0.001), and a 7.2% increase in midthigh muscle area (153 +/- 24 vs 164 +/- 23 cm2, p < 0.001). There were no significant changes in strength or muscle area in the inactive control group. Peak serum CK levels were approximately twofold above baseline (278 +/- 175 vs 133 +/- 88 U/l, p < 0.01) 8 h after the first regular training session. At the end of training, the peak rise in CK levels was also reached 8 h after exercise, but was reduced substantially at the same absolute (p < 0.01) and relative resistance loads (p < 0.01) compared to the first training session. Muscle soreness after exercise was only occasionally reported at the beginning of training and was almost nonexistent after training. These results indicate that middle-aged and older men can safely participate in a total body strength training program, intense enough to produce substantial increases in muscle strength and hypertrophy, without promoting muscle soreness or significant muscle cell disruption.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
B F Hurley; R A Redmond; R E Pratley; M S Treuth; M A Rogers; A P Goldberg
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of sports medicine     Volume:  16     ISSN:  0172-4622     ISO Abbreviation:  Int J Sports Med     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-12-15     Completed Date:  1995-12-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008349     Medline TA:  Int J Sports Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  378-84     Citation Subset:  IM    
Affiliation:
Department of Kinesiology, University of Maryland, College Park, USA.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / anatomy & histology
Aged
Body Composition
Cell Membrane / pathology
Creatine Kinase / blood
Humans
Hypertrophy
Male
Middle Aged
Muscle Contraction
Muscle, Skeletal / pathology*,  physiology*
Oxygen Consumption
Pain / physiopathology,  psychology
Perception
Physical Education and Training
Thigh
Weight Lifting / physiology*
Grant Support
ID/Acronym/Agency:
K08AG00494/AG/NIA NIH HHS; P01-AG04402-6/AG/NIA NIH HHS; R01-AG07660/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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