| Effects of storage time of red blood cell transfusions on the prognosis of coronary artery bypass graft patients. | |
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MedLine Citation:
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PMID: 17002627 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In different centers for cardiothoracic surgery throughout the world, different policies are followed concerning the maximum storage time of to-be-transfused red blood cells (RBCs). The aim in this study was to investigate the possible role of the storage time of RBC transfusions on the outcome of coronary artery bypass graft (CABG) surgery patients. STUDY DESIGN AND METHODS: In a single-center study, all patients who had undergone CABG surgery in the period 1993 until 1999 were identified. Only those patients who had received standard, allogeneic, buffy coat-depleted, unfiltered RBCs in saline-adenine-glucose-mannitol were entered in the analyses (n = 2732). Endpoints were 30-day survival, hospital stay, and intensive care unit (ICU) stay. Storage time of the perioperative RBC transfusions was analyzed in the following four ways: 1) mean storage time of all perioperative RBC transfusions; 2) storage time of the youngest RBC transfusion; 3) storage time of the oldest RBC transfusion; and 4) comparing outcome in patients receiving only RBCs with a storage time below the median storage of 18 days with patients receiving only RBCs with a storage time above the median. RESULTS: The univariate analyses showed a strong correlation between storage time and the endpoints survival and ICU stay, but also a correlation with an established risk factor such as the number of transfusions. The multivariate analyses showed no independent effect of storage time on survival or ICU stay. CONCLUSION: In these analyses, pertaining to 2732 CABG patients, no justification could be found for use of a particular maximum storage time for RBC transfusions in patients undergoing CABG surgery. |
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Authors:
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Leo van de Watering; Jos Lorinser; Michel Versteegh; Rudi Westendord; Anneke Brand |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Transfusion Volume: 46 ISSN: 0041-1132 ISO Abbreviation: Transfusion Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-09-27 Completed Date: 2006-11-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0417360 Medline TA: Transfusion Country: United States |
Other Details:
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Languages: eng Pagination: 1712-8 Citation Subset: IM |
Affiliation:
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Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands. l.vanderwatering@sanquin.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Preservation* Coronary Artery Bypass* / methods, mortality Disease-Free Survival Erythrocyte Transfusion* Female Humans Intensive Care Units Length of Stay Male Middle Aged Multivariate Analysis Perioperative Care* / methods, mortality Retrospective Studies Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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