| Effects of stopping exercise training on epinephrine-induced lipolysis in humans. | |
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MedLine Citation:
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PMID: 6373688 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been reported that in rats endurance exercise training enhances the sensitivity of adipose tissue to the lipolytic action of catecholamines. The purpose of this study was to determine whether endurance training has a similar effect on the lipolytic response to epinephrine in humans. Four days after cessation of training, a constant infusion of epinephrine resulted in a significantly smaller increase in serum free fatty acids (0.57 +/- 0.40 vs. 1.06 +/- 0.30 mM; P less than 0.01) and blood glycerol (0.07 +/- 0.01 vs. 0.12 +/- 0.03 mM; P less than 0.01) and a greater rise in blood lactate (1.24 +/- 0.51 vs. 0.69 +/- 0.44 mM; P less than 0.01) above preinfusion levels than when the subjects were training. No further change in these responses occurred after 2 mo of inactivity. Plasma glucose and glucagon responses to epinephrine remained constant throughout the study. Plasma insulin concentrations before and during epinephrine infusion were higher than in the trained state only after 2 mo of inactivity. These findings suggest that epinephrine-induced lipolysis is enhanced in endurance-exercise-trained individuals but that this adaptation is lost very rapidly after cessation of exercise. |
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Authors:
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W H Martin; E F Coyle; M Joyner; D Santeusanio; A A Ehsani; J O Holloszy |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of applied physiology: respiratory, environmental and exercise physiology Volume: 56 ISSN: 0161-7567 ISO Abbreviation: J Appl Physiol Publication Date: 1984 Apr |
Date Detail:
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Created Date: 1984-07-11 Completed Date: 1984-07-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7801242 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 845-8 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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anatomy & histology Adult Blood Glucose / analysis Body Weight Epinephrine / blood, pharmacology* Fatty Acids, Nonesterified / blood Glucagon / blood Glycerol / blood Humans Insulin / blood Lactates / blood Lipolysis / drug effects* Male Physical Education and Training* |
| Grant Support | |
ID/Acronym/Agency:
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AG-00078/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Lactates; 11061-68-0/Insulin; 51-43-4/Epinephrine; 56-81-5/Glycerol; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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