Document Detail


Effects of stopping exercise training on epinephrine-induced lipolysis in humans.
MedLine Citation:
PMID:  6373688     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been reported that in rats endurance exercise training enhances the sensitivity of adipose tissue to the lipolytic action of catecholamines. The purpose of this study was to determine whether endurance training has a similar effect on the lipolytic response to epinephrine in humans. Four days after cessation of training, a constant infusion of epinephrine resulted in a significantly smaller increase in serum free fatty acids (0.57 +/- 0.40 vs. 1.06 +/- 0.30 mM; P less than 0.01) and blood glycerol (0.07 +/- 0.01 vs. 0.12 +/- 0.03 mM; P less than 0.01) and a greater rise in blood lactate (1.24 +/- 0.51 vs. 0.69 +/- 0.44 mM; P less than 0.01) above preinfusion levels than when the subjects were training. No further change in these responses occurred after 2 mo of inactivity. Plasma glucose and glucagon responses to epinephrine remained constant throughout the study. Plasma insulin concentrations before and during epinephrine infusion were higher than in the trained state only after 2 mo of inactivity. These findings suggest that epinephrine-induced lipolysis is enhanced in endurance-exercise-trained individuals but that this adaptation is lost very rapidly after cessation of exercise.
Authors:
W H Martin; E F Coyle; M Joyner; D Santeusanio; A A Ehsani; J O Holloszy
Related Documents :
18727988 - Blood oxidative stress biomarkers: influence of sex, exercise training status, and diet...
10515398 - Interval versus continuous training in patients with severe copd: a randomized clinical...
17925628 - Immune response to inspiratory muscle training in patients with chronic heart failure.
8282588 - Effects of detraining on endurance capacity and metabolic changes during prolonged exha...
10514108 - Quantitative near-infrared spectroscopy discriminates between mitochondrial myopathies ...
7632768 - Influence of radiolabel on the in vivo processing of intact and fragmented anti-tumour ...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology: respiratory, environmental and exercise physiology     Volume:  56     ISSN:  0161-7567     ISO Abbreviation:  J Appl Physiol Respir Environ Exerc Physiol     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-07-11     Completed Date:  1984-07-11     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  7801242     Medline TA:  J Appl Physiol Respir Environ Exerc Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  845-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / anatomy & histology
Adult
Blood Glucose / analysis
Body Weight
Epinephrine / blood,  pharmacology*
Fatty Acids, Nonesterified / blood
Glucagon / blood
Glycerol / blood
Humans
Insulin / blood
Lactates / blood
Lipolysis / drug effects*
Male
Physical Education and Training*
Grant Support
ID/Acronym/Agency:
AG-00078/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Insulin; 0/Lactates; 51-43-4/Epinephrine; 56-81-5/Glycerol; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Adaptations of skeletal muscle to endurance exercise and their metabolic consequences.
Next Document:  Effect of edema and hemodynamic changes on extravascular thermal volume of the lung.