Document Detail

Effects of stimulatory and depressant drugs on cyclic guanosine 3',5'-monophosphate and adenosine 3',5'-monophosphate levels in mouse brain.
MedLine Citation:
PMID:  181685     Owner:  NLM     Status:  MEDLINE    
Cyclic GMP levels were dose-dependently increased by excitatory drugs such as picrotoxin, pentetrazol, oxotremorine and harmaline in mouse cerebellum and medial forebrain (parts of the cortex, hippocampus, hypothalamus, thalamus, striatum and midbrain) in vivo. Cyclic AMP levels remained unchanged under these conditions. Pretreatment with diazepam completely abolished the effect of picrotoxin and harmaline and significantly reduced the effects of pentetrazol and oxotremorine on cyclic GMP levels, but the tremor due to harmaline and oxotremorine was not blocked. Pretreatment with pentobarbital also prevented or strongly reduced changes in cyclic GMP levels elicited by excitatory drugs without abolishing the tremorigenic effects of harmaline and oxotremorine. Pretreatment with atropine was only effective in blocking cyclic GMP rise and tremor induced by oxotremorine and picrotoxin. Since pentobarbital and diazepam also decreased cyclic GMP levels in a dose-dependent manner in brains of control animals, the changes in cyclic GMP levels observed after administration of excitatory drugs appear to be related to the arousal reaction of the central nervous system.
F A Opmeer; S W Gumulka; V Dinnedahl; P S Sch?nh?fer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  292     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  1976  
Date Detail:
Created Date:  1976-09-25     Completed Date:  1976-09-25     Revised Date:  2010-03-12    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  259-65     Citation Subset:  IM    
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MeSH Terms
Atropine / pharmacology
Brain / metabolism
Brain Chemistry / drug effects*
Convulsants / pharmacology*
Cyclic AMP / metabolism*
Cyclic GMP / metabolism*
Diazepam / pharmacology
Drug Interactions
Harmaline / pharmacology
Oxotremorine / pharmacology
Pentobarbital / pharmacology
Pentylenetetrazole / pharmacology
Picrotoxin / pharmacology
Tremor / chemically induced
gamma-Aminobutyric Acid / metabolism
Reg. No./Substance:
0/Convulsants; 124-87-8/Picrotoxin; 304-21-2/Harmaline; 439-14-5/Diazepam; 51-55-8/Atropine; 54-95-5/Pentylenetetrazole; 56-12-2/gamma-Aminobutyric Acid; 60-92-4/Cyclic AMP; 70-22-4/Oxotremorine; 76-74-4/Pentobarbital; 7665-99-8/Cyclic GMP

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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