| Effects of stimulatory and depressant drugs on cyclic guanosine 3',5'-monophosphate and adenosine 3',5'-monophosphate levels in mouse brain. | |
| | |
MedLine Citation:
|
PMID: 181685 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cyclic GMP levels were dose-dependently increased by excitatory drugs such as picrotoxin, pentetrazol, oxotremorine and harmaline in mouse cerebellum and medial forebrain (parts of the cortex, hippocampus, hypothalamus, thalamus, striatum and midbrain) in vivo. Cyclic AMP levels remained unchanged under these conditions. Pretreatment with diazepam completely abolished the effect of picrotoxin and harmaline and significantly reduced the effects of pentetrazol and oxotremorine on cyclic GMP levels, but the tremor due to harmaline and oxotremorine was not blocked. Pretreatment with pentobarbital also prevented or strongly reduced changes in cyclic GMP levels elicited by excitatory drugs without abolishing the tremorigenic effects of harmaline and oxotremorine. Pretreatment with atropine was only effective in blocking cyclic GMP rise and tremor induced by oxotremorine and picrotoxin. Since pentobarbital and diazepam also decreased cyclic GMP levels in a dose-dependent manner in brains of control animals, the changes in cyclic GMP levels observed after administration of excitatory drugs appear to be related to the arousal reaction of the central nervous system. |
| | |
Authors:
|
F A Opmeer; S W Gumulka; V Dinnedahl; P S Sch?nh?fer |
Related Documents
:
|
7994845 - Abolition of cyclic flow variations in stenosed, endothelium-injured coronary arteries ... 7946965 - Isolation and characterization of the rolipram-sensitive cyclic amp-specific phosphodie... 22718255 - External quality assessment of platelet disorder investigations: results of internation... 15127725 - Versatile pharmacological actions of yc-1: anti-platelet to anticancer. 448165 - Evaporation of diethyltoluamide from human skin in vivo and in vitro. 3992485 - Venous gangrene associated with heparin-induced thrombocytopenia. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Naunyn-Schmiedeberg's archives of pharmacology Volume: 292 ISSN: 0028-1298 ISO Abbreviation: Naunyn Schmiedebergs Arch. Pharmacol. Publication Date: 1976 |
Date Detail:
|
Created Date: 1976-09-25 Completed Date: 1976-09-25 Revised Date: 2010-03-12 |
Medline Journal Info:
|
Nlm Unique ID: 0326264 Medline TA: Naunyn Schmiedebergs Arch Pharmacol Country: GERMANY, WEST |
Other Details:
|
Languages: eng Pagination: 259-65 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Atropine / pharmacology Brain / metabolism Brain Chemistry / drug effects* Convulsants / pharmacology* Cyclic AMP / metabolism* Cyclic GMP / metabolism* Diazepam / pharmacology Drug Interactions Harmaline / pharmacology Male Mice Oxotremorine / pharmacology Pentobarbital / pharmacology Pentylenetetrazole / pharmacology Picrotoxin / pharmacology Tremor / chemically induced gamma-Aminobutyric Acid / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Convulsants; 124-87-8/Picrotoxin; 304-21-2/Harmaline; 439-14-5/Diazepam; 51-55-8/Atropine; 54-95-5/Pentylenetetrazole; 56-12-2/gamma-Aminobutyric Acid; 60-92-4/Cyclic AMP; 70-22-4/Oxotremorine; 76-74-4/Pentobarbital; 7665-99-8/Cyclic GMP |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Adrenal cortex adenylate cyclase. Is Ca2+ involved in ACTH stimulation?
Next Document: The role of presynaptic receptors in the release and synthesis of 3H-dopamine by slices of rat stria...