| Effects of stilbenes on arachidonate metabolism in leukocytes. | |
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MedLine Citation:
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PMID: 3922423 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of various stilbenes (i.e, 3,4',5-trihydroxystilbene, 3,4',5-trihydroxystilbene 3-O-D-glucoside and 2,3,4',5-tetrahydroxystilbene 2-O-D-glucoside) isolated from the roots of Polygonum species on rat peritoneal polymorphonuclear leukocyte lipoxygenase and cyclooxygenase activities were studied. Resveratrol (3,4',5-trihydroxystilbene) was found to inhibit the 5-lipoxygenase product, 5-HETE, and cyclooxygenase products, HHT and thromboxane B2; its concentrations for 50% inhibition (IC50) were 2.72 +/- 0.262 microM for the leukocyte lipoxygenase product, 5-HETE, 0.683 +/- 0.163 microM for the formations of HHT and 0.810 +/- 0.274 microM for the formation of thromboxane B2. Piceid (3,4',5-trihydroxystilbene 3-O-D-glucoside) and 2,3,4',5-tetrahydroxystilbene 2-O-D-glucoside also inhibited the formation of 5-HETE, HHT and thromboxane B2, although less strongly. Their IC50 values were, respectively, 55.3 +/- 15.3 microM and greater than 1000 microM for the formation of 5-HETE, 196.7 +/- 48.0 microM and 300.0 +/- 10.4 microM for the formation of HHT and 251.7 +/- 24.9 microM and 366.7 +/- 37.1 microM for the formation of thromboxane B2. |
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Authors:
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Y Kimura; H Okuda; S Arichi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 834 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1985 Apr |
Date Detail:
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Created Date: 1985-06-25 Completed Date: 1985-06-25 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 275-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arachidonic Acid Arachidonic Acids / metabolism*, pharmacology Cell Aggregation / drug effects Fatty Acids, Unsaturated / blood Hydroxyeicosatetraenoic Acids / biosynthesis Leukocytes / metabolism* Plants, Medicinal Rats Stilbenes / pharmacology* Thromboxane B2 / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 0/Fatty Acids, Unsaturated; 0/Hydroxyeicosatetraenoic Acids; 0/Stilbenes; 506-32-1/Arachidonic Acid; 54397-85-2/Thromboxane B2; 72255-35-7/5-hydroxy-6,8,11,14-eicosatetraenoic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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