| Effects of sternotomy on heart-lung interaction in patients undergoing cardiac surgery receiving pressure-controlled mechanical ventilation. | |
| | |
MedLine Citation:
|
PMID: 17378782 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The key concept underlying the dynamic indexes of preload dependence is the physiological heart-lung interaction. During sternotomy this interaction undergoes various changes, some of which remain unclear. Our primary aim was to investigate how the interaction changes during sternotomy by evaluating pulse pressure variations (PPV) with the chest closed and after sternotomy in patients ventilated using the pressure-controlled mode. METHODS: We prospectively studied 25 patients undergoing coronary artery bypass grafting (CABG) receiving pressure-controlled ventilation. Standard hemodynamic data, PPV and tidal volume delivered were recorded before and after sternotomy, and, with the chest open, before and after positive end-expiratory pressure (PEEP) was applied and inspiratory pressure was increased. RESULTS: Sternotomy left all variables statistically unchanged from values before thoracotomy although in the subgroup of patients with a PPV > 8% (56%) sternotomy significantly reduced PPV (from 14.4 +/- 5.2% to 8.9 +/- 4.5%). With the chest open, when PEEP was applied at 5 cm H(2)O, tidal volume decreased (from 643 +/- 83 to 587 +/- 104 ml) and stroke volume decreased (from 77 +/- 17 to 72 +/- 15 ml) but PPV remained unchanged. When PEEP was discontinued and inspiratory pressure was increased by 5 cm H(2)O, tidal volume increased (from 643 +/- 83 to 814 +/- 89 ml) and PPV increased (from 8.2 +/- 3.9% to 12.3 +/- 6.8%) but stroke volume remained unchanged. CONCLUSIONS: In patients ventilated in the pressure-controlled mode, except those with a pre-sternotomy PPV > 8% (fluid responders), sternotomy leaves standard hemodynamic data and PPV unchanged. When the chest wall is open, cyclic changes (tidal volume) but not continuous changes (PEEP) in intrathoracic pressure directly influence PPV. |
| | |
Authors:
|
R A De Blasi; S Palmisani; L Cigognetti; M Iasenzaniro; R Arcioni; M Mercieri; G Pinto |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Acta anaesthesiologica Scandinavica Volume: 51 ISSN: 0001-5172 ISO Abbreviation: Acta Anaesthesiol Scand Publication Date: 2007 Apr |
Date Detail:
|
Created Date: 2007-03-23 Completed Date: 2007-07-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370270 Medline TA: Acta Anaesthesiol Scand Country: England |
Other Details:
|
Languages: eng Pagination: 441-6 Citation Subset: IM |
Affiliation:
|
Department of Anesthesia and Intensive Care Medicine, University La Sapienza, 2nd Faculty of Medicine, Sant'Andrea Hospital, Rome, Italy. radbl@libero.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anesthesia, General
/
methods Blood Pressure / physiology* Cardiac Output / physiology Central Venous Pressure / physiology Coronary Artery Bypass / methods* Female Heart Rate / physiology Humans Male Middle Aged Monitoring, Intraoperative / methods Positive-Pressure Respiration / methods* Prospective Studies Pulmonary Wedge Pressure / physiology Sternum / surgery Stroke Volume / physiology* Thoracotomy / methods* Tidal Volume / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pre-emptive stellate ganglion block increases the patency of radial artery grafts in coronary artery...
Next Document: Neurogenic pulmonary edema.