Document Detail


Effects of stent stiffness on local haemodynamics with particular reference to wave reflections.
MedLine Citation:
PMID:  14757453     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The placement of a rigid stent within an elastic vessel produces wave reflection sites at the entrance to and exit from the stent. The net haemodynamic effects of these reflections depend critically on the degree of stiffness of the stent and on its length and position within the diseased vessel, variables that have been found to affect the clinical performance of a stent. Here these effects are examined analytically, using a segmented tube model. The results indicate that the presence of the stent within the larger diseased vessel has the effect of producing higher pressure at the vessel entrance than that at exit. This pressure difference, when superimposed on the underlying pressure distribution within the vessel, has the net effect of actually aiding rather than impeding the flow, but the extent of this depends on the length and position of the stent. A short stent placed near the entrance of the diseased vessel may be favoured clinically for producing the least perturbation in the underlying haemodynamics and thus reducing the chance of restenosis, while a long stent placed near the exit may be favoured for producing a positive pressure difference and thus aiding the flow.
Authors:
H Alderson; M Zamir
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomechanics     Volume:  37     ISSN:  0021-9290     ISO Abbreviation:  J Biomech     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-02-03     Completed Date:  2004-06-03     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  339-48     Citation Subset:  IM    
Affiliation:
Department of Mathematical Sciences, University of New Brunswick, Saint John, Canada E2L 4L5.
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MeSH Terms
Descriptor/Qualifier:
Blood Flow Velocity
Blood Pressure
Blood Vessel Prosthesis*
Blood Vessels / physiopathology*
Computer Simulation
Elasticity
Equipment Failure Analysis / methods*
Hemorheology / methods*
Models, Cardiovascular*
Stents*
Stress, Mechanical
Vascular Capacitance
Vascular Resistance
Vascular Surgical Procedures*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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