Document Detail


Effects of stent design and atherosclerotic plaque composition on arterial wall biomechanics.
MedLine Citation:
PMID:  19090628     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To examine the solid mechanical effects of varying stent design and atherosclerotic plaque stiffness on the biomechanical environment induced in a diseased artery wall model.
METHODS: Computational modeling techniques were employed to investigate the final radius of the lumen and artery wall stresses after stent implantation. Two stent designs were studied (one stiff and one less stiff). The stenotic artery was modeled as an axisymmetrical diseased vessel with a 20% stenosis by diameter. The material properties of the diseased tissue in the artery models varied. Atherosclerotic plaques half as stiff (0.5x), of equal stiffness (1.0x), or twice as stiff (2.0x) as the artery wall were investigated.
RESULTS: Final lumen radius was dependent on stent design, and the stiffer stent deformed the artery to an approximately 10% greater radius than the more compliant design. Alternatively, circumferential stress levels were dependent on both stent design and plaque material properties. Overall, the stiffer stent subjected the artery wall to much higher stress values than the more compliant design, with differences in peak values of 0.50, 0.31, and 0.09 MPa for the 2.0x, 1.0x, and 0.5x stiff plaques, respectively.
CONCLUSION: Evidence suggests that a judicious choice of stent design can minimize stress while maintaining a patent lumen in stenotic arteries. If confronted with a rigid, calcified plaque, stent design is more important, as design differences can impose dramatically different stress fields, while still providing arterial patency. Alternatively, stent design is not as much of an issue when treating a soft, lipid-laden plaque, as stress fields do not vary significantly among stent designs.
Authors:
Lucas H Timmins; Clark A Meyer; Michael R Moreno; James E Moore
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists     Volume:  15     ISSN:  1526-6028     ISO Abbreviation:  J. Endovasc. Ther.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-18     Completed Date:  2009-03-12     Revised Date:  2013-06-04    
Medline Journal Info:
Nlm Unique ID:  100896915     Medline TA:  J Endovasc Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  643-54     Citation Subset:  IM    
Affiliation:
Department of Biomedical Engineering, Texas A&M University, College Station, TX 78843-3120, USA.
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MeSH Terms
Descriptor/Qualifier:
Arteries / pathology,  physiopathology,  surgery*
Atherosclerosis / pathology,  physiopathology,  surgery*
Biomechanics
Blood Vessel Prosthesis Implantation / adverse effects,  instrumentation*
Calcinosis / pathology,  physiopathology,  surgery*
Computer Simulation
Constriction, Pathologic
Elasticity
Finite Element Analysis
Humans
Materials Testing
Models, Cardiovascular*
Prosthesis Design
Prosthesis Failure
Stents*
Stress, Mechanical
Vascular Patency
Grant Support
ID/Acronym/Agency:
R01 EB000115/EB/NIBIB NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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