| Effects of statins on the recovery of olfactory function in a 3-methylindole-induced anosmia mouse model. | |
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MedLine Citation:
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PMID: 22487282 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Despite the importance of olfactory function, no effective medications have been identified to treat olfactory disorders. This study was performed to evaluate the functional recovery of olfaction damaged by 3-methylindole (3MI) in a mouse model with hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins). METHODS: In a randomized placebo-controlled trial, 24 healthy female BALB/c mice (aged 9-10 weeks and weighing 18-20 g each) were randomly allocated to statin-treated or control groups. Olfactory loss was induced by i.p. injections of 3MI. Atorvastatin (10 mg/kg) or normal saline was then administered per os with a gastric tube for 3 weeks. The effects of treatment were evaluated by food-finding tests and Western blot analysis. RESULTS: Both groups showed complete losses of olfactory function 1 week after 3MI injection. Three weeks after 3MI injection, 9 of the 12 mice in the statin-treated group (75%) passed a food-finding test, in which they were able to find the food within 3 minutes, at least two times out of three trials. However, only two mice in the control group (16.6%) passed the food-finding test, and this difference was statistically significant (p = 0.004; chi-square test). The expression level of the olfactory marker protein was also elevated in the statin-treated group (p = 0.030; Wilcoxon rank sum test). CONCLUSION: Statins are associated with recovery of olfaction after 3MI injection in a mouse model. |
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Authors:
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Hyo Yeol Kim; Joon Ho Kim; Hun-Jong Dhong; Ki Ryung Kim; Seung-Kyu Chung; Soo-Chan Chung; Jeong Min Kang; Yong Gi Jung; Seong Yun Jang; Sang Duk Hong |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of rhinology & allergy Volume: 26 ISSN: 1945-8932 ISO Abbreviation: Am J Rhinol Allergy Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-04-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101490775 Medline TA: Am J Rhinol Allergy Country: United States |
Other Details:
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Languages: eng Pagination: 81-4 Citation Subset: IM |
Affiliation:
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Department of Otorhinolaryngology-Head and Neck Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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