Document Detail

Effects of statins on the liver: clinical analysis of patients with ischemic stroke.
MedLine Citation:
PMID:  21518599     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Statins are one of the most common agents prescribed for ischemic stroke patients, but their side effects on the liver are worrisome to both physicians and patients. This study aimed to analyze the features and related factors of the hepatic side effects of statins in patients with ischemic stroke.
METHODS: Four hundred and eighty-one patients with ischemic stroke who had been treated with statins at our department from July 1, 2008 to June 30, 2009 were investigated retrospectively. Liver function, including alanine aminotransferase (ALT) and aspartate aminotransferase (AST), within 6 months after they began to use statins and related factors were analyzed.
RESULTS: The incidence of mild ALT and AST elevation, less than three times the upper limit of normal, and the incidence of moderate elevation, ALT and AST levels 3 - 10 times the upper limit of normal, in ischemic stroke patients who had been treated with statins were 2.3% and 2.1%, respectively. These incidences were higher than in patients with common hyperlipidemia or coronary heart disease. The relatively high incidence was associated with older age (≥ 65 years) and chronic liver diseases, and was not related to the type of stroke, gender, and reduction of low-density lipoprotein. The levels of ALT and AST normalized after withdrawal of statins or lowering the dosage. None of the patients developed hepatic failure.
CONCLUSIONS: Asymptomatic elevation of ALT and AST after administration of statins is more likely to occur in ischemic stroke patients than in others, and the elevation is related to age and chronic liver diseases. However, statins are still safe for ischemic stroke patients.
Li-San Zhang; Zheng-Xia Liu; Wen Lü; Xing-Yue Hu
Related Documents :
3979749 - Protoporphyrin metabolic balance in human protoporphyria.
11929709 - Dendritic cell subtypes in autoimmune liver diseases; decreased expression of hla dr an...
17384469 - Incidence of side-effects of ticlopidine after sirolimus-eluting stent implantation.
18379139 - Retrospective evaluation of serum markers apri and ast/alt for assessing liver fibrosis...
11167689 - The value of amino-terminal propeptide of type iii procollagen in routine screening for...
15122769 - Asialoglycoprotein receptor facilitates hemolysis in patients with alcoholic liver cirr...
6791939 - Ileal dysfunction and bacterial overgrowth in patients with crohn's disease.
8077889 - Serum ferritin and transferrin saturation in patients with chronic alcoholic and non-al...
18281909 - Cardiovascular considerations in patients undergoing gastrointestinal endoscopy.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chinese medical journal     Volume:  124     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-04-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  China    
Other Details:
Languages:  eng     Pagination:  897-900     Citation Subset:  IM    
Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Prediction of contrast-induced nephropathy in diabetics undergoing elective percutaneous coronary in...
Next Document:  Endothelial progenitor cells with Alzheimer's disease.