Document Detail

Effects of statin treatments on coronary plaques assessed by volumetric virtual histology intravascular ultrasound analysis.
MedLine Citation:
PMID:  19628193     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We evaluated the effects of statin treatments for each component of coronary plaques.
BACKGROUND: Effects of statin treatments on coronary plaques have not been sufficiently evaluated.
METHODS: One hundred patients without significant lesion stenosis underwent baseline and 12-month follow-up virtual histology (VH) intravascular ultrasound (IVUS) studies and were treated with statin for 1 year. They were randomized to simvastatin (20 mg/day, n = 50) or rosuvastatin (10 mg/day, n = 50). With VH-IVUS, plaque was characterized as fibrotic, fibrofatty, dense calcium, and necrotic core.
RESULTS: In overall patients, necrotic core volume significantly reduced (15.7 to 13.7 mm(3), p = 0.010) and fibrofatty plaque volume increased (4.3 to 5.5 mm(3), p = 0.006) after statin treatments for 1 year. There were no significant differences of changes in either plaque component volume between simvastatin- and rosuvastatin-treated subgroups. In serial comparisons during 1-year follow-up, simvastatin treatment did not achieve statistically significant changes in fibrofatty plaque (4.1 to 5.1 mm(3), p = 0.131) and necrotic core volume (15.8 to 14.4 mm(3), p = 0.216). However, there was a significant decrease in necrotic core volume (15.5 to 13.0 mm(3), p = 0.015) and an increase in fibrofatty plaque volume (4.5 to 5.9 mm(3), p = 0.017) in the rosuvastatin-treated subgroup.
CONCLUSIONS: Serial volumetric VH-IVUS analysis showed that statin treatments might be associated with significant changes in necrotic core and fibrofatty plaque volume in overall patients. The changes in both plaques' component volume were not statistically different between simvastatin- and rosuvastatin-treated subgroup.
Myeong-Ki Hong; Duk-Woo Park; Cheol-Whan Lee; Seung-Whan Lee; Young-Hak Kim; Duk-Hyun Kang; Jae-Kwan Song; Jae-Joong Kim; Seong-Wook Park; Seung-Jung Park
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  JACC. Cardiovascular interventions     Volume:  2     ISSN:  1876-7605     ISO Abbreviation:  JACC Cardiovasc Interv     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-24     Completed Date:  2009-10-02     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  101467004     Medline TA:  JACC Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  679-88     Citation Subset:  IM    
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MeSH Terms
Calcinosis / drug therapy,  ultrasonography
Coronary Angiography
Coronary Artery Disease / drug therapy*,  radiography,  ultrasonography*
Fluorobenzenes / therapeutic use*
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Middle Aged
Predictive Value of Tests
Pyrimidines / therapeutic use*
Severity of Illness Index
Simvastatin / therapeutic use*
Sulfonamides / therapeutic use*
Time Factors
Treatment Outcome
Ultrasonography, Interventional*
User-Computer Interface*
Reg. No./Substance:
0/Fluorobenzenes; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrimidines; 0/Sulfonamides; 287714-41-4/rosuvastatin; AGG2FN16EV/Simvastatin
Comment In:
JACC Cardiovasc Interv. 2009 Jul;2(7):697-700   [PMID:  19628195 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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