Document Detail


Effects of statin treatment on serum sex steroids levels and autonomic and erectile function.
MedLine Citation:
PMID:  18387399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To investigate the effect of statin treatment on serum sex steroid levels, heart rate variability, erectile function, and libido in patients with hyperlipidemia. METHODS: A total of 74 patients (mean age 44.7 +/- 7.1 years) with hyperlipidemia were enrolled into this study. After a cardiac examination, the serum lipid levels were measured, and the 24-hour Holter monitoring, heart rate variability, and autonomic test results were also evaluated. Erectile function was assessed using the International Index of Erectile Function (IIEF) questionnaire. Later, atorvastatin 40 mg/day was initiated in all patients and used for the subsequent 12 months. All diagnostic tests (cardiac, biochemical, and autonomic and the IIEF questionnaire) were performed again at 6 and 12 months of follow-up. RESULTS: A statistically significant decrease was found in the serum lipid levels at 6 months (P <0.05). In contrast, the average IIEF scores (24.7 +/- 6.4 at baseline) had increased to 25.0 +/- 4.9 and 26.1 +/- 5.9 at 6 and 12 months of follow-up, respectively. Although the parasympathetic activities increased and sympathetic activities decreased with atorvastatin treatment, these changes were not statistically significant (P >0.05). In paired comparison, significant differences were found among the IIEF scores of the three periods (P = 0.013). The difference was more evident after 6 months of treatment (IIEF(1vs2) = 0.475; IIEF(1vs3) = 0.027; IIEF(2vs3) = 0.012). CONCLUSIONS: Although improvement in the lipid profile occurred early during the statin treatment, restoration of erectile function appeared later, which could be attributed to the restoration of endothelial functions by lowered serum lipid levels.
Authors:
M Tolga Doğru; M Murad Başar; Ali Simşek; Ercan Yuvanç; Mahmut Güneri; Haksun Ebinç; Ertan Batislam
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Urology     Volume:  71     ISSN:  1527-9995     ISO Abbreviation:  Urology     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-04     Completed Date:  2008-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  703-7     Citation Subset:  IM    
Affiliation:
Department of Cardiology, University of Kirikkale School of Medicine, Kirikkale, Republic of Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adult
Autonomic Nervous System / drug effects*
Follow-Up Studies
Gonadal Steroid Hormones / blood*
Heart Rate / drug effects
Heptanoic Acids / pharmacology*,  therapeutic use
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*,  therapeutic use
Hyperlipidemias / blood,  drug therapy,  physiopathology*
Libido / drug effects
Lipids / blood
Male
Middle Aged
Penile Erection / drug effects*
Pyrroles / pharmacology*,  therapeutic use
Chemical
Reg. No./Substance:
0/Gonadal Steroid Hormones; 0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Lipids; 0/Pyrroles; 110862-48-1/atorvastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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