Document Detail

Effects of starvation and protein deficiency on the acute carbon tetrachloride-induced hepatotoxicity.
MedLine Citation:
PMID:  6961968     Owner:  NLM     Status:  MEDLINE    
The effects of starvation and protein-deficient diet on the acute carbon tetrachloride (CCl4)-induced hepatotoxicity of the mice were studied histologically and histochemically. A total of 69 male mice (C57BL/6) were used and carbon tetrachloride was administered by a single subcutaneous injection at a dose of 0.1 mg/10 g body weight after starvation for 24 hours and feeding with protein-deficient diet for one month. The changes were examined consecutively. It was shown the the CCl4-induced hepatotoxicity was exaggerated by starvation and that the regeneration after centrilobular necrosis due to CCl4 administration was retarded under this condition. In the CCl4-treated group on protein-deficient diet, the centrilobular liver cells seemed to be less responsive to CCl4.
K Yoshimine; M Takagi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Bulletin of Tokyo Medical and Dental University     Volume:  29     ISSN:  0040-8921     ISO Abbreviation:  Bull. Tokyo Med. Dent. Univ.     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1983-04-07     Completed Date:  1983-04-07     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0405503     Medline TA:  Bull Tokyo Med Dent Univ     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  37-46     Citation Subset:  D; IM    
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MeSH Terms
Carbon Tetrachloride Poisoning / complications*,  pathology
Dietary Proteins / administration & dosage
Drug-Induced Liver Injury*
Liver Diseases / pathology
Liver Regeneration
Mice, Inbred C57BL
Protein Deficiency / pathology*
Reg. No./Substance:
0/Dietary Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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