Document Detail

Effects of a standardized oral fat load on vascular remodelling markers in healthy subjects.
MedLine Citation:
PMID:  20359487     Owner:  NLM     Status:  MEDLINE    
The most adequate way to experimentally reproduce the post-prandial lipemia condition appears to be the administration of a standardized oral fat load (OFL) to fasting patients. We studied the effects of a standardized OFL on markers of vascular remodelling in healthy subjects. We enrolled 286 Caucasians aged >or= 18 of either sex. The OFL was given after a 12-h fast. Blood samples were drawn before and 3, 6, 9 and 12h after the fat load. The following parameters were evaluated: body mass index (BMI), blood glucose (BG), systolic blood pressure (SBP), diastolic blood pressure (DBP), lipid profile, nitrites and nitrates, adiponectin (ADP), metalloproteinase-2 (MMP-2) and metalloproteinase-9 (MMP-9). High density lipoprotein-cholesterol (HDL-C) decrease was present in subjects after 6h. Triglycerides (Tg) change was observed after 6h. Nitrites/nitrates variation was observed after 6 and 9h during OFL. Adiponectin level was decreased after 6 and 9h during OFL. Both MMP-2 and MMP-9 levels were higher after 6h during OFL. We observed that nitrites/nitrates and ADP significantly decreased and MMP-2 and MMP-9 significantly increased after a standardized OFL. Other studies need to confirm the direct acute effects of post-prandial lipemia on vascular damage.
Giuseppe Derosa; Ilaria Ferrari; Angela D'Angelo; Sibilla A T Salvadeo; Elena Fogari; Alessia Gravina; Roberto Mereu; Ilaria Palumbo; Pamela Maffioli; Sabrina Randazzo; Arrigo F G Cicero
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study     Date:  2010-03-29
Journal Detail:
Title:  Microvascular research     Volume:  80     ISSN:  1095-9319     ISO Abbreviation:  Microvasc. Res.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-01     Completed Date:  2010-12-07     Revised Date:  2012-04-09    
Medline Journal Info:
Nlm Unique ID:  0165035     Medline TA:  Microvasc Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  110-5     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
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MeSH Terms
Adiponectin / blood
Biological Markers / blood*
Blood Glucose / drug effects,  metabolism
Cholesterol / blood
Cholesterol, HDL / blood,  drug effects
Cholesterol, LDL / blood,  drug effects
Dietary Fats / administration & dosage,  pharmacology*
Endothelium, Vascular / drug effects*,  physiopathology
Hyperlipidemias / blood*
Matrix Metalloproteinase 2 / blood
Matrix Metalloproteinase 9 / blood
Middle Aged
Nitrates / blood
Nitrites / blood
Postprandial Period
Triglycerides / blood
Reg. No./Substance:
0/ADIPOQ protein, human; 0/Adiponectin; 0/Biological Markers; 0/Blood Glucose; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Dietary Fats; 0/Nitrates; 0/Nitrites; 0/Triglycerides; 57-88-5/Cholesterol; EC Metalloproteinase 2; EC Metalloproteinase 9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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