Document Detail


Effects of spontaneous and forced running on activation of hypothalamic corticotropin-releasing hormone neurons in rats.
MedLine Citation:
PMID:  17067638     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Corticotropin-releasing hormone (CRH)-containing neurons in the hypothalamic paraventricular nucleus (PVN) are known to be activated during physical or psychological stress, and play an important role as one of the central activators of integrated stress response. Physical exercise has also been suggested as one of the stressors activating CRH neurons in the PVN. Spontaneous wheel running (SWR) has recently been reported to result in improved mental health or mood, unlike treadmill running that commonly forces the animal to run. Thus, forced running may strongly induce an activation of CRH neurons compared with spontaneous running, and spontaneous running may not represent a strong stressor. However, whether the effects of spontaneous running on activation of CRH neurons in the PVN differ from those of forced running is unknown. The present study examined the activity of CRH neurons in 1-h forced wheel running (FWR) and SWR using c-Fos/CRH immunohistochemistry in male Wistar rats. No significant differences in 1-h running distance were observed between FWR and SWR, indicating that amount of work was almost equal between exercises. Number of double-labeled neurons for c-Fos and CRH in the PVN was markedly higher in FWR than in SWR. In addition, no significant differences in Fos expression in the LC, which is related to various stress responses, were found between FWR and SWR. These results indicate that FWR strongly activates CRH neurons in the PVN compared with SWR, suggesting that spontaneous running is not an intense stressor even though running distance does not differ significantly from forced running.
Authors:
Shinya Yanagita; Seiichiro Amemiya; Satoko Suzuki; Ichiro Kita
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-09-30
Journal Detail:
Title:  Life sciences     Volume:  80     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-25     Completed Date:  2007-02-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  356-63     Citation Subset:  IM    
Affiliation:
Department of Kinesiology, Tokyo Metropolitan University, 1-1 Minami-ohsawa, Hachioji, Tokyo 192-0397, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Corticotropin-Releasing Hormone / metabolism*
Fluorescent Antibody Technique, Indirect
Immunoenzyme Techniques
Male
Neurons / metabolism*
Paraventricular Hypothalamic Nucleus / cytology,  metabolism*
Physical Conditioning, Animal / physiology*
Proto-Oncogene Proteins c-fos / metabolism
Rats
Rats, Wistar
Running / physiology*
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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