| Effects of spironolactone treatment on an experimental model of chronic aortic valve regurgitation. | |
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MedLine Citation:
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PMID: 22953675 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND AND AIM OF THE STUDY: Aortic regurgitation (AR) is a disease for which there is currently no effective medical treatment. It has been shown previously in an experimental model of AR that the renin-angiotensin-aldosterone system (RAAS) plays a major role, and that medications blocking the RAAS are effective to protect against left ventricular (LV) hypertrophy and also help to maintain a normal systolic function. The role of aldosterone receptor blockers in this disease has never been evaluated. Thus, the effects were studied of the aldosterone receptor blocking agent spironolactone in a model of chronic AR in rats. METHODS: The effects of a six-month treatment with spironolactone were evaluated in adult Wistar rats with severe AR, compared to sham-operated and untreated AR animals. RESULTS: Spironolactone treatment decreased the total heart weight. In addition, the LV expression of atrial natriuretic peptide mRNA was decreased by spironolactone treatment, as was the expression of collagen 1 and LOX1 mRNAs. Left ventricular fibrosis was decreased by spironolactone treatment. CONCLUSION: Spironolactone protected against volume-overload cardiomyopathy in this model of aortic valve regurgitation. The predominant protective effect was a decrease in myocardial fibrosis. |
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Authors:
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Adnane Zendaoui; Dominic Lachance; Elise Roussel; Jacques Couet; Marie Arsenault |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of heart valve disease Volume: 21 ISSN: 0966-8519 ISO Abbreviation: J. Heart Valve Dis. Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-09-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9312096 Medline TA: J Heart Valve Dis Country: England |
Other Details:
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Languages: eng Pagination: 478-86 Citation Subset: IM |
Affiliation:
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Groupe de Recherche sur les Valvulopathies, Centre de Recherche de l'Institut universitaire de Cardiologie et pneumologie de Québec, Université Laval, Québec, Canada. |
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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/MOP-61818//Canadian Institutes of Health Research |
| Comments/Corrections | |
Comment In:
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J Heart Valve Dis. 2012 Jul;21(4):473-5
[PMID:
22953673
]
J Heart Valve Dis. 2012 Jul;21(4):476-7 [PMID: 22953674 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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