| Effects of sphingosine 1-phosphate, a naturally occurring biologically active lysophospholipid, on the rat cardiovascular system. | |
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MedLine Citation:
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PMID: 10875754 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent studies have indicated that sphingosine 1-phosphate (Sph-1-P) is released into the blood flow from activated platelets upon stimulation to exhibit a wide spectrum of biological functions. The purpose of the present study was to assess the acute cardiovascular effects of circulating Sph-1-P in the in vivo rat model. Intravenous administration of Sph-1-P decreased the heart rate, ventricular contraction and blood pressure, while it hardly affected the atrioventricular and intraventricular conduction. Sph-1-P did not affect the adenylate cyclase activities of the membrane preparations made from the right atrium and left ventricle. These results suggest that functional receptors like lysophospholipid receptor Edg-1, which can inhibit adenylate cyclase via Gi protein, are lacking in the rat heart. Moreover, these observations will provide a clue to better understand the various types of Sph-1-P-related pathophysiological processes. |
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Authors:
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A Sugiyama; N N Aye; Y Yatomi; Y Ozaki; K Hashimoto |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Japanese journal of pharmacology Volume: 82 ISSN: 0021-5198 ISO Abbreviation: Jpn. J. Pharmacol. Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-10-11 Completed Date: 2000-11-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2983305R Medline TA: Jpn J Pharmacol Country: JAPAN |
Other Details:
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Languages: eng Pagination: 338-42 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Yamanashi Medical University Nakakoma-gun, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenylate Cyclase
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metabolism Animals Blood Pressure / drug effects Cardiovascular System / drug effects* Electrocardiography / drug effects Heart Rate / drug effects Lysophospholipids* Male Myocardium / enzymology Rats Rats, Sprague-Dawley Signal Transduction / drug effects, physiology Sphingosine / analogs & derivatives*, pharmacology* Ventricular Function, Left / drug effects Ventricular Pressure / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Lysophospholipids; 123-78-4/Sphingosine; 26993-30-6/sphingosine 1-phosphate; EC 4.6.1.1/Adenylate Cyclase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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