| Effects of sphincterotomy and pudendal nerve transection on the anal sphincter in a rat model. | |
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MedLine Citation:
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PMID: 19571711 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Our objective was to define anal resting pressure and electromyography of the normal rat anal sphincter and investigate the short-term effects of both mechanical trauma to the anal sphincter muscles and pudendal nerve transection. METHODS: Forty-five virgin female Sprague-Dawley rats were randomly allotted to three groups: controls (n = 21), sphincterotomy (n = 12), and pudendal nerve transection (n = 12). Anal pressure was monitored using a saline-filled balloon connected to a pressure transducer. Anal pressure and electromyography of the anal sphincter with use of a needle electrode were recorded both before and after injury or succinylcholine administration. RESULTS: Anal pressure data were consistent with rhythmic pressure contractions. Succinylcholine significantly reduced both pressure and electromyography signals. Electromyography amplitude and frequency decreased after nerve transection but not after sphincterotomy. The histology showed that the rat anal anatomy has muscular components that compare with human anatomy. The sphincterotomy group showed injury to the anal sphincters and the sphincter anatomy of the nerve transection group appeared similar to the control group. The anal pressure wave appears to be created by synergistic activity of both striated and smooth muscle of the anal sphincter. CONCLUSION: The female rat is a suitable and reliable model for studying effect of direct and indirect injury to the anal sphincters. |
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Authors:
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Massarat Zutshi; Levilester B Salcedo; Paul J Zaszczurynski; Tracy L Hull; Robert S Butler; Margot S Damaser |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diseases of the colon and rectum Volume: 52 ISSN: 1530-0358 ISO Abbreviation: Dis. Colon Rectum Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-07-02 Completed Date: 2009-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372764 Medline TA: Dis Colon Rectum Country: United States |
Other Details:
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Languages: eng Pagination: 1321-9 Citation Subset: IM |
Affiliation:
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Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio, USA. zutshim@ccf.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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physiology Anal Canal / injuries*, innervation, surgery* Animals Disease Models, Animal* Electromyography Female Muscle Contraction / physiology Muscle Strength Muscle, Striated / innervation*, physiopathology*, surgery Pressure Rats Rats, Sprague-Dawley Reproducibility of Results |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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