Document Detail


Effects of space environment on embryonic growth up to hatching of salamander eggs fertilized and developed during orbital flights.
MedLine Citation:
PMID:  12101347     Owner:  NASA     Status:  MEDLINE    
Abstract/OtherAbstract:
In vertebrates, only few experiments have been performed in microgravity to study the embryonic development from fertilization. To date, these concern only amphibian and fish. We report here a study on the embryonic development of Pleurodeles waltl (urodele amphibian) eggs oviposited in microgravity. The experiment was performed twice on board the Mir space station and the data obtained included video recording and morphological, histological and immunocytological analyses. The data confirm that the microgravity conditions have effects during the embryonic period, particularly during cleavage and neurulation, inducing irregular segmentation and abnormal closure of the neural tube. Moreover, we observed several abnormalities hither to undescribed corresponding to cortical cytoplasm movements, a decrease of cell adhesion and a loss of cells. These abnormalities were temporary and subsequently reversible. The young larvae that hatched during the flight displayed normal morphology and swimming behavior after landing. The results obtained in the urodele Pleurodeles waltl are in accordance with those observed earlier in the anuran Xenopus laevis and in the fish Oryzias latipes.
Authors:
Lydie Gualandris-Parisot; David Husson; Alain Bautz; Danielle Durand; Paulette Kan; Christian Aimar; Herve Membre; Anne-Marie Duprat; Christian Dournon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Uchū Seibutsu Kagaku     Volume:  16     ISSN:  0914-9201     ISO Abbreviation:  Biol. Sci. Space     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-07-08     Completed Date:  2002-09-27     Revised Date:  2009-06-04    
Medline Journal Info:
Nlm Unique ID:  100972048     Medline TA:  Biol Sci Space     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  3-11     Citation Subset:  S    
Affiliation:
Center of Developmental Biology, Paul Sabatier University, Toulouse cedex, France.
Space Flight Mission:
Flight Experiment; Mir Project; long duration; manned
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Physiological Phenomena
Choline O-Acetyltransferase / metabolism
Cleavage Stage, Ovum
Embryo, Nonmammalian / abnormalities,  physiology*
Embryonic Development
Female
Larva
Motor Activity
Nervous System / embryology*
Ovum
Pleurodeles / abnormalities,  embryology,  growth & development,  physiology*
Space Flight*
Swimming
Weightlessness*
Chemical
Reg. No./Substance:
EC 2.3.1.6/Choline O-Acetyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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