Document Detail


Effects of soy isoflavone extract supplements on blood pressure in adult humans: systematic review and meta-analysis of randomized placebo-controlled trials.
MedLine Citation:
PMID:  20577121     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Reported effects of different soy products on blood pressure vary. This systematic review and meta-analysis was performed to clarify the effects of soy isoflavone extract supplements on systolic and diastolic blood pressure (SBP and DBP) in adult humans.
METHODS: PubMed, CENTRAL, ICHUSHI, and CNKI were searched in June 2009 for relevant randomized placebo-controlled trials. Study data and indicators of methodological validity were independently extracted by two authors using predefined data fields. Meta-analysis was carried out in Review Manager 5.0.22.
RESULTS: Searches identified 3740 articles, of which 14 randomized controlled trials (789 participants) were included. Daily ingestion of 25-375 mg soy isoflavones (aglycone equivalents) for 2-24 weeks significantly decreased SBP by 1.92 mmHg (95% confidence interval -3.45 to -0.39; P = 0.01) compared with placebo (heterogeneity P = 0.39, fixed effect model) in adults with normal blood pressure and prehypertension. The effect was not lost on sensitivity analysis. Subgroup analyses suggest greater effects in studies longer than 3 months, in Western populations, at lower doses, and in studies at lower risk of bias. Soy isoflavones did not affect DBP [-0.13 (95% confidence interval -1.03 to 0.78) mmHg, P = 0.78; heterogeneity P = 0.20, fixed effect model].
CONCLUSION: Soy isoflavone extracts significantly decreased SBP but not DBP in adult humans, and no dose-response relationship was observed. Further studies are needed to address factors related to the observed effects of soy isoflavones on SBP and to verify the effect in hypertensive patients.
Authors:
Kyoko Taku; Ning Lin; Donglian Cai; Jianwei Hu; Xiaohui Zhao; Yumei Zhang; Peiyu Wang; Melissa K Melby; Lee Hooper; Mindy S Kurzer; Shoichi Mizuno; Yoshiko Ishimi; Shaw Watanabe
Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of hypertension     Volume:  28     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-16     Completed Date:  2011-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  1971-82     Citation Subset:  IM    
Affiliation:
Information Center, National Institute of Health and Nutrition, Tokyo, Japan. takuk@nih.go.jp
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure / drug effects*
Diastole / drug effects
Dietary Supplements
Humans
Isoflavones / pharmacology*
Plant Extracts / pharmacology*
Randomized Controlled Trials as Topic
Soybeans*
Systole / drug effects
Chemical
Reg. No./Substance:
0/Isoflavones; 0/Plant Extracts
Comments/Corrections
Comment In:
J Hypertens. 2011 Feb;29(2):400-1; author reply 401-2   [PMID:  21191281 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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