Document Detail

Effects of soy isoflavone extract supplements on blood pressure in adult humans: systematic review and meta-analysis of randomized placebo-controlled trials.
MedLine Citation:
PMID:  20577121     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Reported effects of different soy products on blood pressure vary. This systematic review and meta-analysis was performed to clarify the effects of soy isoflavone extract supplements on systolic and diastolic blood pressure (SBP and DBP) in adult humans.
METHODS: PubMed, CENTRAL, ICHUSHI, and CNKI were searched in June 2009 for relevant randomized placebo-controlled trials. Study data and indicators of methodological validity were independently extracted by two authors using predefined data fields. Meta-analysis was carried out in Review Manager 5.0.22.
RESULTS: Searches identified 3740 articles, of which 14 randomized controlled trials (789 participants) were included. Daily ingestion of 25-375 mg soy isoflavones (aglycone equivalents) for 2-24 weeks significantly decreased SBP by 1.92 mmHg (95% confidence interval -3.45 to -0.39; P = 0.01) compared with placebo (heterogeneity P = 0.39, fixed effect model) in adults with normal blood pressure and prehypertension. The effect was not lost on sensitivity analysis. Subgroup analyses suggest greater effects in studies longer than 3 months, in Western populations, at lower doses, and in studies at lower risk of bias. Soy isoflavones did not affect DBP [-0.13 (95% confidence interval -1.03 to 0.78) mmHg, P = 0.78; heterogeneity P = 0.20, fixed effect model].
CONCLUSION: Soy isoflavone extracts significantly decreased SBP but not DBP in adult humans, and no dose-response relationship was observed. Further studies are needed to address factors related to the observed effects of soy isoflavones on SBP and to verify the effect in hypertensive patients.
Kyoko Taku; Ning Lin; Donglian Cai; Jianwei Hu; Xiaohui Zhao; Yumei Zhang; Peiyu Wang; Melissa K Melby; Lee Hooper; Mindy S Kurzer; Shoichi Mizuno; Yoshiko Ishimi; Shaw Watanabe
Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of hypertension     Volume:  28     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-16     Completed Date:  2011-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  1971-82     Citation Subset:  IM    
Information Center, National Institute of Health and Nutrition, Tokyo, Japan.
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MeSH Terms
Blood Pressure / drug effects*
Diastole / drug effects
Dietary Supplements
Isoflavones / pharmacology*
Plant Extracts / pharmacology*
Randomized Controlled Trials as Topic
Systole / drug effects
Reg. No./Substance:
0/Isoflavones; 0/Plant Extracts
Comment In:
J Hypertens. 2011 Feb;29(2):400-1; author reply 401-2   [PMID:  21191281 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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