| Effects of soy isoflavone extract supplements on blood pressure in adult humans: systematic review and meta-analysis of randomized placebo-controlled trials. | |
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MedLine Citation:
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PMID: 20577121 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Reported effects of different soy products on blood pressure vary. This systematic review and meta-analysis was performed to clarify the effects of soy isoflavone extract supplements on systolic and diastolic blood pressure (SBP and DBP) in adult humans. METHODS: PubMed, CENTRAL, ICHUSHI, and CNKI were searched in June 2009 for relevant randomized placebo-controlled trials. Study data and indicators of methodological validity were independently extracted by two authors using predefined data fields. Meta-analysis was carried out in Review Manager 5.0.22. RESULTS: Searches identified 3740 articles, of which 14 randomized controlled trials (789 participants) were included. Daily ingestion of 25-375 mg soy isoflavones (aglycone equivalents) for 2-24 weeks significantly decreased SBP by 1.92 mmHg (95% confidence interval -3.45 to -0.39; P = 0.01) compared with placebo (heterogeneity P = 0.39, fixed effect model) in adults with normal blood pressure and prehypertension. The effect was not lost on sensitivity analysis. Subgroup analyses suggest greater effects in studies longer than 3 months, in Western populations, at lower doses, and in studies at lower risk of bias. Soy isoflavones did not affect DBP [-0.13 (95% confidence interval -1.03 to 0.78) mmHg, P = 0.78; heterogeneity P = 0.20, fixed effect model]. CONCLUSION: Soy isoflavone extracts significantly decreased SBP but not DBP in adult humans, and no dose-response relationship was observed. Further studies are needed to address factors related to the observed effects of soy isoflavones on SBP and to verify the effect in hypertensive patients. |
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Authors:
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Kyoko Taku; Ning Lin; Donglian Cai; Jianwei Hu; Xiaohui Zhao; Yumei Zhang; Peiyu Wang; Melissa K Melby; Lee Hooper; Mindy S Kurzer; Shoichi Mizuno; Yoshiko Ishimi; Shaw Watanabe |
Publication Detail:
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Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of hypertension Volume: 28 ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-16 Completed Date: 2011-01-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 1971-82 Citation Subset: IM |
Affiliation:
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Information Center, National Institute of Health and Nutrition, Tokyo, Japan. takuk@nih.go.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure
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drug effects* Diastole / drug effects Dietary Supplements Humans Isoflavones / pharmacology* Plant Extracts / pharmacology* Randomized Controlled Trials as Topic Soybeans* Systole / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Isoflavones; 0/Plant Extracts |
| Comments/Corrections | |
Comment In:
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J Hypertens. 2011 Feb;29(2):400-1; author reply 401-2
[PMID:
21191281
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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