| Effects of soy diet on inflammation-induced primary and secondary hyperalgesia in rat. | |
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MedLine Citation:
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PMID: 20060762 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Soy consumption is said to prevent or treat atherosclerosis, cancer, pain, and memory deficits, but experimental and clinical evidence to support these claims are lacking. We used in vivo models of inflammation to determine whether a soy diet reduces primary or secondary hyperalgesia. In all three experiments, rats were fed either a soy- or casein-based diet for at least 2 weeks before induction of inflammation and for the duration of experiments. Mechanical and heat paw withdrawal thresholds and edema were measured before and several times after induction of inflammation. Primary hyperalgesia was assessed in two models: unilateral intraplantar injection with 0.1 ml of 25% complete Freund's adjuvant (CFA) or 0.1 ml of 1% carrageenan. Unilateral injection of the intra-articular knee space with 25% CFA (0.1 ml) was used to determine the effects of soy in a model of secondary hyperalgesia. Following intraplantar injection of CFA, soy-fed animals exhibited significantly less paw edema, mechanical allodynia, and heat hyperalgesia compared to casein-fed animals. In the carrageenan model of paw inflammation, soy-fed animals were also less allodynic to mechanical stimuli, than were casein-fed animals, but showed no diet based differences in paw edema or heat hyperalgesia. Soy diet did not affect any of the outcome measures after the intra-articular injection of CFA. Our results suggest that a soy diet significantly decreases aspects of inflammation-induced primary, but not secondary, hyperalgesia in rats. |
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Authors:
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Jasenka Borzan; Jill M Tall; Chengshui Zhao; Richard A Meyer; Srinivasa N Raja |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-01-08 |
Journal Detail:
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Title: European journal of pain (London, England) Volume: 14 ISSN: 1532-2149 ISO Abbreviation: Eur J Pain Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-23 Completed Date: 2010-12-06 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9801774 Medline TA: Eur J Pain Country: England |
Other Details:
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Languages: eng Pagination: 792-8 Citation Subset: IM |
Copyright Information:
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Copyright 2009 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University, USA. jborzan1@jhmi.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Diet* Freund's Adjuvant / pharmacology Hyperalgesia / chemically induced, physiopathology* Inflammation / chemically induced, physiopathology* Male Pain Measurement Physical Stimulation Rats Rats, Sprague-Dawley Soy Foods* Statistics, Nonparametric |
| Grant Support | |
ID/Acronym/Agency:
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P50 AT000437-050002/AT/NCCAM NIH HHS; P50 AT00437/AT/NCCAM NIH HHS |
| Chemical | |
Reg. No./Substance:
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9007-81-2/Freund's Adjuvant |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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