Document Detail


Effects of source-detector distance of near infrared spectroscopy on the measurement of the cortical hemodynamic response in infants.
MedLine Citation:
PMID:  17884584     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One of the practical problems in neuroimaging using near infrared spectroscopy (NIRS) is to choose an appropriate source-detector distance to maximize the sensitivity to cerebral blood oxygenation and to improve the spatial resolution for mapping cortical activation. While NIRS has attracted increasing attention in neuroimaging in infants, there has been no report of comparative data regarding source-detector distance for the infant brain. In the present study, 9 quietly sleeping 3-month-old infants were exposed to 3-s speech sounds, and hemodynamic responses over the bilateral temporal cortices were assessed by using multiple pairs of source and detector of NIR light with varying distances (1, 2, 3 and 4 cm) and varying intensities (0.6 and 1.2 mW). The statistical analyses of the group-averaged hemodynamic responses and the frequency analyses of the signal-to-noise ratios revealed that a 2-cm source-detector distance with 0.6-mW NIR light provided the highest sensitivity to cortical responses. This indicates that NIRS can be used to detect the activation of the cortical regions, in the infant brain, by using the source-detector distance scaled to the smaller head size of infants and a relatively low intensity of NIR light compared to the ones that have been routinely used in adult studies.
Authors:
Gentaro Taga; Fumitaka Homae; Hama Watanabe
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Publication Detail:
Type:  Journal Article     Date:  2007-08-15
Journal Detail:
Title:  NeuroImage     Volume:  38     ISSN:  1053-8119     ISO Abbreviation:  Neuroimage     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-15     Completed Date:  2008-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9215515     Medline TA:  Neuroimage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  452-60     Citation Subset:  IM    
Affiliation:
Graduate School of Education, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. taga@p.u-tokyo.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Analysis of Variance
Cerebral Cortex / blood supply*
Cerebrovascular Circulation / physiology*
Female
Hemodynamics / physiology*
Hemoglobins / metabolism
Humans
Infant
Male
Oxyhemoglobins / metabolism
Sensitivity and Specificity
Spectrophotometry, Infrared / methods
Chemical
Reg. No./Substance:
0/Hemoglobins; 0/Oxyhemoglobins; 9008-02-0/deoxyhemoglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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