Document Detail

Effects of some purified saponins on transmural potential difference in mammalian small intestine.
MedLine Citation:
PMID:  20702304     Owner:  NLM     Status:  In-Data-Review    
The effect of a range of saponins, commonly present in foods or dietary supplements, on the potential difference (PD) across the mucosa of the rat small intestine in vitro has been examined. Saponins from Gypsophila, guar, alfalfa, Quillaja, clover and liquorice together with glycoalkaloids from the potato and tomato were examined. The typical response was an immediate reduction in PD, although there was considerable variation in the response to particular compounds. Amongst the factors affecting the nature and magnitude of the de-polarizing effect were pH, solubility and the chemical form of the saponin. In agreement with the findings of others, glycyrrhizic acid, isolated from liquorice root, was found to exhibit a protective effect against the activity of a more potent saponin. The observations are discussed in the light of the known physiological activities of plant saponins and the regular, or excessive, consumption of certain foods or dietary supplements.
J M Gee; K R Price; C L Ridout; I T Johnson; G R Fenwick
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology in vitro : an international journal published in association with BIBRA     Volume:  3     ISSN:  0887-2333     ISO Abbreviation:  Toxicol In Vitro     Publication Date:  1989  
Date Detail:
Created Date:  2010-08-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8712158     Medline TA:  Toxicol In Vitro     Country:  England    
Other Details:
Languages:  eng     Pagination:  85-90     Citation Subset:  -    
Agricultural and Food Research Council Institute of Food Research, Norwich Laboratory, Colney Lane, Norwich, Norfolk NR4 7UA, England.
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