| Effects of some poorly digestible carbohydrates on bile acid bacterial transformations in the rat. | |
| | |
MedLine Citation:
|
PMID: 2789979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of ingestion of poorly digestible carbohydrates on bacterial transformations of cholic acid and beta-muricholic acid were studied in rats fed on increasing levels of lactose, lactulose, amylomaize or potato starches. Each level was given for 3 weeks and, at the end of each dietary treatment, bile acid faecal composition was analysed and a group of six rats was killed every 4 h during 24 h to determine the amounts of fermented carbohydrate and fermentation characteristics (caecal pH, volatile fatty acids (VFA) and lactic acid concentrations). Fermentation of carbohydrates decreased caecal pH and enhanced caecal VFA and lactic acid concentrations. Irrespective of the poorly digestible carbohydrate, the variation of bacterial transformation always occurred in the same way: the bacterial transformation of beta-muricholic acid into hyodeoxycholic acid was the first to disappear, while omega-muricholic acid formation increased; second, cholic acid transformation decreased and finally all bile acid transformations were strongly affected. There was a significant correlation between bile acid transfer and the minimal caecal pH in vivo. This effect of pH was similar in vitro. To determine whether the levels of bacteria which transformed bile acids were modified, rats fed on the highest amounts of poorly digestible carbohydrates were introduced into isolators and carbohydrate feeding was stopped. Caecal pH recovered its initial value but bile acid transformations remained changed, suggesting that the intestinal microflora were modified by ingestion of fermentable carbohydrates. |
| | |
Authors:
|
C Andrieux; D Gadelle; C Leprince; E Sacquet |
Related Documents
:
|
961679 - A new substrate for the rapid evaluation of enteric microbial overgrowth. 6464789 - N-acetylpenicillamine potentiation of biliary excretion of methyl mercury: influence of... 3999929 - Metabolism and cholestatic effect of 3 alpha-hydroxy-7 xi-methyl-5 beta-cholanoic acid. 10695269 - Mechanism for the prevention of cholestasis involving cytochrome p4503a overexpression. 7662719 - Inhibition of bile acid conjugation by cyclosporin a. 3371139 - Influence of age, intestinal transit time, and dietary composition on fecal bile acid p... 11972679 - Effect of acetic acid consumption on clinical laboratory values in the dog. 2820639 - Influence of inactivated feline retrovirus on feline alpha interferon and immunoglobuli... 465979 - Familial renal hypouricaemia: two additional cases with uric acid lithiasis. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The British journal of nutrition Volume: 62 ISSN: 0007-1145 ISO Abbreviation: Br. J. Nutr. Publication Date: 1989 Jul |
Date Detail:
|
Created Date: 1989-11-08 Completed Date: 1989-11-08 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 103-19 Citation Subset: IM |
Affiliation:
|
Laboratorie d'Ecologie Microbienne, INRA, Centre de Recherche de Jouy, Jouy en Josas, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bacteria / metabolism* Bile Acids and Salts / metabolism* Cecum / anatomy & histology, metabolism Dietary Carbohydrates / administration & dosage, pharmacology* Digestion* Feces / analysis Fermentation Male Rats Rats, Inbred F344 |
| Chemical | |
Reg. No./Substance:
|
0/Bile Acids and Salts; 0/Dietary Carbohydrates |
| Comments/Corrections | |
Erratum In:
|
Br J Nutr 1989 Sep;62(2):following 525 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Parental care and overprotection of children with cystic fibrosis.
Next Document: Effects of dietary copper deficiency on male offspring of heterozygous brindled mice.