| Effects of some plant lectins on hydrogen peroxide release from macrophages induced with streptococcal preparation OK-432. | |
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MedLine Citation:
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PMID: 7399666 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Concanavalin A and phytohemagglutinin were found to cause marked inhibition of H2O2 release from macrophages induced with killed streptococci (preparation OK-432). The inhibitory effect of these two lectins on the H2O2 release from macrophages was observed with spontaneous and wheat germ lectin-triggered H2O2 release. This suggests that the lectins act directly on the macrophage H2O2-releasing function, per se, but not on the wheat germ lectin-H2O2 release-enhancing process. Concanavalin A exhibited its inhibitory action on macrophage H2O2 release by specific binding to D-mannopyranoside receptor sites on the macrophage cell surface. Galactose-binding lectins, peanut agglutinin, and soybean agglutinin failed to inhibit, but, on the other hand, slightly enhanced macrophage H2O2 release. The effect of these five lectins on the phagocytosis of latex particles by macrophages was tested. Wheat germ lectin, concanavalin A, and phytohemagglutinin significantly depressed the macrophage phagocytosis, whereas peanut agglutinin and soybean agglutinin failed to show any inhibitory action. |
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Authors:
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H Tomioka; H Saito |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Infection and immunity Volume: 28 ISSN: 0019-9567 ISO Abbreviation: Infect. Immun. Publication Date: 1980 May |
Date Detail:
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Created Date: 1980-10-21 Completed Date: 1980-10-21 Revised Date: 2013-06-12 |
Medline Journal Info:
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Nlm Unique ID: 0246127 Medline TA: Infect Immun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 336-43 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Agents / pharmacology* Concanavalin A / pharmacology Female Hydrogen Peroxide / metabolism* Lectins / pharmacology* Macrophages / drug effects, metabolism* Mice Mice, Inbred C3H Phagocytosis / drug effects Phytohemagglutinins / pharmacology Picibanil / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Biological Agents; 0/Lectins; 0/Phytohemagglutinins; 11028-71-0/Concanavalin A; 39325-01-4/Picibanil; 7722-84-1/Hydrogen Peroxide |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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