| Effects of some drugs on human cord blood erythrocyte carbonic anhydrases I and II: an in vitro study. | |
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MedLine Citation:
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PMID: 21851212 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In the present study, we purified hcbCA I and II from human cord blood erythrocytes using by Sepharose-4B-l tyrosine-sulfanilamide affinity gel chromatography. Also, it was checked the inhibition effects of ampicillin sulfate, ceftriaxone, ceftizoxime and ranitidine on hcbCA I and hcbCA II. IC(50) values for ceftriaxone, ceftizoxime and ranitidine were found to be 27.l, 79.4 and 55.5 µM for hcbCA I and of 21.0, 79.1 and 66.1 µM for hcbCA II, respectively. According to these results, Ampicillin sulfate inhibited only hcbCAII and IC(50) values of this antibiotic was found to be 56.8 µM. All these substances were found non-competitive inhibitors. It is important to study the inhibition effects of these drugs on hcbCA I and II izoenzymes. Because, pregnant woman is take all of these substance. For this reason, these drugs should be carefully used and the dosage should be very well ordered to minimize side effects. |
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Authors:
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Murat Cankaya; Mehmet Aktas; Mehmet Kuzucu; Ilhami Gül; T Abdulkadir Coban |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-18 |
Journal Detail:
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Title: Journal of enzyme inhibition and medicinal chemistry Volume: - ISSN: 1475-6374 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101150203 Medline TA: J Enzyme Inhib Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Erzincan University, Science and Art Faculty, Biology Department , Erzincan , Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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