Document Detail

Effects of some connective-tissue active drugs on protocollagen proline hydroxylase activity.
MedLine Citation:
PMID:  212824     Owner:  NLM     Status:  MEDLINE    
The effect on protocollagen proline hydroxylase of drugs reported to be capable of inducing the lupus erythematosus syndrome and in some way acting on connective tissue and inflammation was studied in an in vitro system for the hydroxylation of 14C-Pro-labelled protocollagen. Some derivatives were also studied. It was found that benzoic acid and phenothiazine derivatives, hydroxyphenols, (+)catechin, beta-amino propionitrile, certain B vitamins, dihydrazinophthalazine, cysteine and dimethylcysteine were inhibitors of PPH. The chelation of Fe2+ions by the compounds mentioned is suggested to be essential.
N Blumenkrantz; G Asboe-Hansen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of rheumatology     Volume:  7     ISSN:  0300-9742     ISO Abbreviation:  Scand. J. Rheumatol.     Publication Date:  1978  
Date Detail:
Created Date:  1978-12-27     Completed Date:  1978-12-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0321213     Medline TA:  Scand J Rheumatol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  123-7     Citation Subset:  IM    
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MeSH Terms
Benzoates / pharmacology
Chick Embryo
Connective Tissue / drug effects*,  metabolism
Phenols / pharmacology
Phenothiazines / pharmacology
Procollagen / metabolism*
Procollagen-Proline Dioxygenase / metabolism*
Sulfonamides / pharmacology
Urea / analogs & derivatives,  pharmacology
Vitamins / pharmacology
Reg. No./Substance:
0/Benzoates; 0/Phenols; 0/Phenothiazines; 0/Procollagen; 0/Sulfonamides; 0/Vitamins; 57-13-6/Urea; EC Dioxygenase

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