| Effects of somatostatin analogues on acromegalic cardiomyopathy: results from a prospective study using cardiac magnetic resonance. | |
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MedLine Citation:
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PMID: 20348836 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Left ventricular (LV) hypertrophy is the main finding of patients with active acromegaly at cardiac magnetic resonance (CMR). The aim of the study was to evaluate heart changes in acromegalic patients treated with somatostatin analogues (SMSA) using CMR. DESIGN AND PATIENTS: This was a prospective study. Fourteen consecutive patients (8 women, mean age 46+/-10 yr) with untreated active acromegaly were submitted to CMR and 2D-color Doppler echocardiography before and after a 6-month SMSA course. MEASUREMENTS: LV volume, mass (LVM) and wall thickness. RESULTS: CMR: Mean LVM and LVM index (i) decreased from 151+/-17 g and 77+/-9 g/m2, to 144+/-24 g and 70+/-12 g/m2, respectively (p=0.047 and p<0.0001, respectively); LV hypertrophy reverted in 6 out of 10 patients (p=0.016). Systolic function, evaluated by measuring LV ejection fraction remained normal in all patients (67+/-11%). There was not a correlation between changes in LVMi and changes in serum IGF-I concentrations. However, patients with controlled disease had higher reduction of LVMi than those with uncontrolled acromegaly (DeltaLVMi, -8.2+/-4.2 vs 4.0+/-5.3 p<0.05). 2D-echo cardiography: Mean LVMi decreased from 110+/-24 g/m2 to 100+/-20 g/m2 (p=0.026); hypertrophy, revealed in 5 patients (36%) at baseline, reversed in 2 patients (p=0.500) after SMSA; abnormal diastolic function [evaluated by isovolumic relaxation time or early (E) to late of atrial (A) peak velocities ratio] found in 4 patients (29%) at the study entry, improved in a patient. Systolic function remained within the normal range in all patients during the study period. CONCLUSIONS: CMR detects changes in LVMi in most patients with acromegaly treated with SMSA, which are more evident if the disease is controlled. |
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Authors:
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F Bogazzi; M Lombardi; E Strata; G Aquaro; M Lombardi; C Urbani; V Di Bello; C Cosci; C Sardella; E Talini; E Martino |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of endocrinological investigation Volume: 33 ISSN: 1720-8386 ISO Abbreviation: J. Endocrinol. Invest. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-03-29 Completed Date: 2010-06-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: Italy |
Other Details:
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Languages: eng Pagination: 103-8 Citation Subset: IM |
Affiliation:
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Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy. f.bogazzi@endoc.med.unipi.it |
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| MeSH Terms | |
Descriptor/Qualifier:
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Acromegaly
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blood,
complications*,
pathology Adult Cardiomyopathies / drug therapy*, etiology*, pathology Echocardiography Female Growth Hormone / blood Heart Ventricles / pathology Humans Hypertrophy, Left Ventricular / drug therapy, etiology, pathology Insulin-Like Growth Factor I / analysis Magnetic Resonance Imaging* Male Middle Aged Prospective Studies Somatostatin / analogs & derivatives* |
| Chemical | |
Reg. No./Substance:
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51110-01-1/Somatostatin; 67763-96-6/Insulin-Like Growth Factor I; 9002-72-6/Growth Hormone |
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