| Effects of soluble mediators generated during growth of the Landschütz ascites carcinoma on the chemotaxis of normal and Corynebacterium parvum-stimulated peritoneal leucocytes. | |
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MedLine Citation:
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PMID: 6466553 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence of ascites fluid on the chemokinetic and chemotactic responses of mouse peritoneal leucocytes was investigated using modified Boyden chambers and the 'leading front' technique. The migration of normal cells towards endotoxin-activated mouse serum was significantly enhanced at high concentrations of fluid (40 and 20%) but was inhibited at lower concentrations (5 and 1%). By comparison, the chemotactic responsiveness of cells harvested 3 days after Corynebacterium parvum (C. parvum) injection was uniformly and more markedly increased over a wide range of fluid concentrations (0.1-50%). These effects were attributed to the presence of strong chemokinetic and chemotactic material in ascites fluid, which was not inactivated by heating. The activity was also demonstrated in the serum of tumour-bearing animals, was present to a much lesser extent in inflammatory exudate fluid and was absent from normal mouse serum. Detailed morphological studies of migrating cells revealed that although the ascites fluid contained a potent chemo-attractant for neutrophils, it inhibited the migration of mononuclear cells. |
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Authors:
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L C McIntosh; A W Thomson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of experimental pathology Volume: 65 ISSN: 0007-1021 ISO Abbreviation: Br J Exp Pathol Publication Date: 1984 Aug |
Date Detail:
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Created Date: 1984-10-17 Completed Date: 1984-10-17 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 0372543 Medline TA: Br J Exp Pathol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 441-51 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ascitic Fluid / immunology* Carcinoma / immunology* Chemotaxis, Leukocyte* Endotoxins / pharmacology Female Leukocytes / immunology, ultrastructure Mice Mice, Inbred Strains Microscopy, Electron Propionibacterium acnes / immunology |
| Chemical | |
Reg. No./Substance:
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0/Endotoxins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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