Document Detail

Effects of sodium nitroprusside-induced controlled hypotension on pancreatic function assessed by pancreatitis-associated protein in patients undergoing radical prostatectomy.
MedLine Citation:
PMID:  12200953     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: Controlled hypotension may alter organ blood flow and tissue oxygenation. The aim of the study was to investigate whether induced hypotension using sodium nitroprusside alters pancreatic function assessed by pancreatitis-associated protein concentrations in the blood.
METHODS: Thirty patients undergoing elective radical prostatectomy were allocated randomly into two groups: (a) hypotension group: sodium nitroprusside was administered to lower mean arterial pressure to approximately 50 mmHg; (b) control group: no hypotension was used, mean arterial pressure was kept > 70 mmHg. Pancreatitis-associated protein and lipase were measured in arterial blood samples: after induction of anaesthesia (T1), at the end of surgery (T2), 2 h (T3) and 24 h (T4) postoperatively.
RESULTS: Pancreatitis-associated protein plasma concentrations increased significantly in patients in the hypotensive group (from 2.8 +/- 1.1 to 5.5 +/- 2.0 micrograms L-1 at T4) and pancreatitis-associated protein plasma concentrations were significantly higher in comparison with controls (5.5 +/- 2.0 versus 3.5 +/- 2.4 micrograms L-1) at T4. Lipase concentrations showed a similar course in both groups. None of the patients showed clinical signs of pancreatitis.
CONCLUSIONS: Controlled hypotension during surgery was associated with a small but significant increase in pancreatitis-associated protein compared with controls. The absence of concomitant elevation in lipase concentrations and a lack of clinical evidence of pancreatitis damage suggest that hypotension induces mild pancreatic stress.
S N Piper; S W Suttner; W H Maleck; B Kumle; G Haisch; J Boldt
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Retracted Publication    
Journal Detail:
Title:  European journal of anaesthesiology     Volume:  19     ISSN:  0265-0215     ISO Abbreviation:  Eur J Anaesthesiol     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-08-30     Completed Date:  2003-02-25     Revised Date:  2011-06-29    
Medline Journal Info:
Nlm Unique ID:  8411711     Medline TA:  Eur J Anaesthesiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  609-13     Citation Subset:  IM    
Klinikum Ludwigshafen, Department of Anaesthesiology and Intensive Care Medicine, Bremserstrasse 79, D-67063 Ludwigshafen, Germany.
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MeSH Terms
Antigens, Neoplasm / blood*
Biological Markers / blood
Hypotension, Controlled*
Lectins, C-Type / blood*
Lipase / blood*
Middle Aged
Nitroprusside / pharmacology*
Pancreas / drug effects*,  physiology
Prostatectomy / methods
Tumor Markers, Biological / blood*
Vasodilator Agents / pharmacology*
Reg. No./Substance:
0/Antigens, Neoplasm; 0/Biological Markers; 0/Lectins, C-Type; 0/Tumor Markers, Biological; 0/Vasodilator Agents; 0/pancreatitis-associated protein; 15078-28-1/Nitroprusside; EC
Retraction In:
Eur J Anaesthesiol. 2011 Jun;28(6):469   [PMID:  21540660 ]

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