| Effects of sodium nitroprusside-induced controlled hypotension on pancreatic function assessed by pancreatitis-associated protein in patients undergoing radical prostatectomy. | |
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MedLine Citation:
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PMID: 12200953 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVE: Controlled hypotension may alter organ blood flow and tissue oxygenation. The aim of the study was to investigate whether induced hypotension using sodium nitroprusside alters pancreatic function assessed by pancreatitis-associated protein concentrations in the blood. METHODS: Thirty patients undergoing elective radical prostatectomy were allocated randomly into two groups: (a) hypotension group: sodium nitroprusside was administered to lower mean arterial pressure to approximately 50 mmHg; (b) control group: no hypotension was used, mean arterial pressure was kept > 70 mmHg. Pancreatitis-associated protein and lipase were measured in arterial blood samples: after induction of anaesthesia (T1), at the end of surgery (T2), 2 h (T3) and 24 h (T4) postoperatively. RESULTS: Pancreatitis-associated protein plasma concentrations increased significantly in patients in the hypotensive group (from 2.8 +/- 1.1 to 5.5 +/- 2.0 micrograms L-1 at T4) and pancreatitis-associated protein plasma concentrations were significantly higher in comparison with controls (5.5 +/- 2.0 versus 3.5 +/- 2.4 micrograms L-1) at T4. Lipase concentrations showed a similar course in both groups. None of the patients showed clinical signs of pancreatitis. CONCLUSIONS: Controlled hypotension during surgery was associated with a small but significant increase in pancreatitis-associated protein compared with controls. The absence of concomitant elevation in lipase concentrations and a lack of clinical evidence of pancreatitis damage suggest that hypotension induces mild pancreatic stress. |
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Authors:
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S N Piper; S W Suttner; W H Maleck; B Kumle; G Haisch; J Boldt |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Retracted Publication |
Journal Detail:
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Title: European journal of anaesthesiology Volume: 19 ISSN: 0265-0215 ISO Abbreviation: Eur J Anaesthesiol Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-08-30 Completed Date: 2003-02-25 Revised Date: 2011-06-29 |
Medline Journal Info:
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Nlm Unique ID: 8411711 Medline TA: Eur J Anaesthesiol Country: England |
Other Details:
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Languages: eng Pagination: 609-13 Citation Subset: IM |
Affiliation:
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Klinikum Ludwigshafen, Department of Anaesthesiology and Intensive Care Medicine, Bremserstrasse 79, D-67063 Ludwigshafen, Germany. wolfgang_maleck@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antigens, Neoplasm / blood* Biological Markers / blood Humans Hypotension, Controlled* Lectins, C-Type / blood* Lipase / blood* Male Middle Aged Nitroprusside / pharmacology* Pancreas / drug effects*, physiology Prostatectomy / methods Tumor Markers, Biological / blood* Vasodilator Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Neoplasm; 0/Biological Markers; 0/Lectins, C-Type; 0/Tumor Markers, Biological; 0/Vasodilator Agents; 0/pancreatitis-associated protein; 15078-28-1/Nitroprusside; EC 3.1.1.3/Lipase |
| Comments/Corrections | |
Retraction In:
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Eur J Anaesthesiol. 2011 Jun;28(6):469
[PMID:
21540660
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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