Document Detail

Effects of sodium intake on inherited hypertension in the rat.
MedLine Citation:
PMID:  4143537     Owner:  NLM     Status:  MEDLINE    
The effect of sodium chloride intake on systolic blood-pressure was studied in genetic hypertensive Wistar rats. In these animals hypertension can develop on a sodium-"free" diet, but the height to which the blood-pressure rises is related to the sodium intake; increasing the amount of potassium in the diet promotes sodium excretion and ameliorates the hypertension. It is suggested that this form of inherited hypertension may be determined by two different sets of autosomal alleles only one of which is sodium-dependent.
W J Louis; R Tabei; S Spector
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  2     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1971 Dec 
Date Detail:
Created Date:  1986-03-04     Completed Date:  1986-03-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1283-6     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure / drug effects*
Diet, Sodium-Restricted*
Hypertension / genetics*,  physiopathology
Potassium Chloride / administration & dosage
Rats, Inbred SHR
Sodium / metabolism
Sodium Chloride / administration & dosage*
Time Factors
Reg. No./Substance:
7440-23-5/Sodium; 7447-40-7/Potassium Chloride; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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