| Effects of sodium bicarbonate on VO2 kinetics during heavy exercise. | |
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MedLine Citation:
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PMID: 15514504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Sodium bicarbonate was used to investigate the effect of blood pH on VO2 kinetics during heavy exercise. METHODS: On separate days, 10 active subjects performed two 6-min cycling bouts (208 +/- 12 W) at 25 W above their ventilatory threshold. Each subject ingested 0.3 g x kg(-1) of sodium bicarbonate with approximately 1 L of water or water alone 1 h before exercise. VO2 kinetics were examined by means of a three-component mono-exponential model. RESULTS: Bicarbonate ingestion caused a significant increase in the preexercise blood pH (7.512 +/- 0.009 vs 7.425 +/- 0.007; P < 0.001). In the bicarbonate trial, the time constant for the rapid component (27.9 +/- 3.5 s) was slower than the control trial (20.8 +/- 2.4 s; P = 0.017). The higher blood pH after bicarbonate ingestion would have diminished local blood flow and caused a leftward shift of the oxygen-hemoglobin dissociation curve both of which would slow oxygen delivery to working muscle. In addition, bicarbonate ingestion diminished the amplitude of the slow component 29% (463 +/- 43 vs 649 +/- 53 mL x min(-1); P = 0.040). The primary cause of the slow component during heavy exercise is fatigue of working fibers and an accompanying increase of motor unit recruitment. Elevated plasma bicarbonate concentration is reported to stimulate the efflux of H from muscle fibers and to increase intramuscular pH. CONCLUSIONS: The slower time constant during the rapid component suggested that oxygen delivery is a limiting factor of VO2 kinetics during the onset of heavy exercise. Also, these results imply that bicarbonate ingestion diminished fatigue in working fibers during the slow component. |
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Authors:
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Fred W Kolkhorst; Robert S Rezende; Susan S Levy; Michael J Buono |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: 36 ISSN: 0195-9131 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-10-29 Completed Date: 2005-03-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: United States |
Other Details:
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Languages: eng Pagination: 1895-9 Citation Subset: IM; S |
Affiliation:
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Department of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA 92182-7251, USA. fred.kolkhorst@sdsu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Imbalance
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blood Adult Exercise / physiology* Female Humans Hydrogen-Ion Concentration / drug effects Kinetics Male Oxygen Consumption / drug effects* Regression Analysis Sodium Bicarbonate / pharmacology* |
| Chemical | |
Reg. No./Substance:
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144-55-8/Sodium Bicarbonate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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