Document Detail

Effects of smoking and age on chronic obstructive pulmonary disease in Japan.
MedLine Citation:
PMID:  16141629     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The Global Initiative for Chronic Obstructive Lung Disease guidelines recommended a forced expiratory volume at one second per forced vital capacity as a standard diagnostic criterion of chronic obstructive pulmonary disease (COPD). A few reports on the risk factors of COPD have used the standard diagnostic criteria. In our study, the effects of age and smoking on COPD in Japan under the standard diagnosis criteria were evaluated. METHODS: Subjects were 11,460 participants aged 25-74 years during health check-ups including spirometry at the Toyota Community Medical Center in Japan. Logistic regression analyses with or without COPD as a dependent variable and age as an independent variable were conducted among non-smokers. The ratio of the observed number of COPD cases in former and current smokers to the number expected for non-smokers with the same distribution of age (O/E) was calculated. RESULTS: The proportion of males incurring COPD significantly increased with age, and the O/E for former and current male smokers was significantly higher than one, i.e., O/E (95% confidence interval) for current smokers with a Brinkman Index of <400, 400-799, and 800+ were 3.10 (2.00-4.81), 2.78 (2.05-3.73), and 4.76 (3.65-6.19), respectively. Among females, the O/E for current smokers with a Brinkman Index of <400, and 400-799 were significantly higher than one. CONCLUSION: Age and smoking were shown to constitute strong risk factors for COPD under the standard diagnostic criteria.
Shigeko Kojima; Hiroki Sakakibara; Shinichi Motani; Kunihiko Hirose; Fumio Mizuno; Madoka Ito; Shuji Hashimoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of epidemiology / Japan Epidemiological Association     Volume:  15     ISSN:  0917-5040     ISO Abbreviation:  J Epidemiol     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-09-05     Completed Date:  2005-10-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607688     Medline TA:  J Epidemiol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  113-7     Citation Subset:  IM    
Division of Hygiene, Department of Medicine, Fujita Health University, Aichi, Japan.
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MeSH Terms
Age Factors
Japan / epidemiology
Logistic Models
Middle Aged
Pulmonary Disease, Chronic Obstructive / diagnosis,  epidemiology*
Respiratory Function Tests
Risk Factors
Smoking / adverse effects*

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